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Lifecourse CVD Risk and Midlife Cognitive Trajectories and Brain Aging: Implications for Alzheimer's and Dementia Prevention

Determinants of cognitive aging may begin decades prior to the development of pathological brain changes, but it is unknown whether risk factors such as hypertension and diabetes exert their influence as early as young adulthood. In this CARDIA Year 35 ancillary study, we plan to expand cognitive testing to assess 10-year cognitive change and address: 1) independent associations of 10-year midlife cognitive decline with average level and trend in cardiovascular disease (CVD) risk factors including BMI, blood pressure, and fasting glucose, assessed over 35 years from young adulthood to midlife; 2) association of 10-year midlife cognitive decline with level and trend in subclinical CVD markers derived from carotid ultrasound, coronary CT, and echocardiography; and 3) whether CVD risk factors and subclinical CVD markers are associated with brain aging indices in midlife, derived from brain MRI data obtained on 700 CARDIA participants at Year 30.
Investigator: Sidney, Stephen
Funder: National Institute on Aging