Can hydroxychloroquine prevent preeclampsia and preterm delivery in lupus pregnancy?Pregnant women with lupus are at high risk to develop preeclampsia and preterm delivery. This work leverages three large population-based databases with detailed prescription and clinical data to determine whether use of hydroxychloroquine during pregnancy among women with lupus reduces the risk of preeclampsia and preterm delivery disentangling these outcomes from the effects of potential mediators. This study will provide key information on hydroxychloroquine use and prescription practices to improve the analytic paradigm and inform our clinical understanding hydroxychloroquine use in lupus pregnancy.
Investigator: Hedderson, Monique
Funder: National Institute of Arthritis and Musculoskeletal and Skin Diseases