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Comparison of type 2 diabetes pharmacotherapy regimens using targeted learning

This study is designed to help patients with type 2 diabetes and their clinicians identify which glucose-lowering medications among SGLT2 inhibitors, GLP-1 receptor agonists, DPP4 inhibitors, or Sulfonylureas have the most favorable effects on heart health and other patient-important outcomes; inform the timing of medication initiation; and explore whether medication benefits apply equally to all adults with type 2 diabetes, or are different based on age, sex, race/ethnicity, baseline heart health status, baseline renal function, or other factors. Inferences are based on a modern causal inference methodology, Targeted Learning, applied within a trial emulation framework.
Investigator: Neugebauer, Romain
Funder: Patient-Centered Outcomes Research Institute