Andrew P. Ambrosy, MD

andrew.p.ambrosy@kp.org

Kaiser Permanente Researcher Profiles

Ambrosy, Andrew

Andrew P. Ambrosy, MD, is a practicing non-invasive cardiologist at Kaiser Permanente San Francisco Medical Center and a clinician-investigator at Kaiser Permanente Northern California (KPNC) Division of Research. Dr. Ambrosy has research interests in cardiovascular and metabolic conditions, with a particular focus on ischemic heart disease and heart failure. He also has methodological expertise in generating real-world evidence through health services, implementation science, and pragmatic clinical trials. He is the KPNC Regional Assistant Medical Director of the Clinical Trials Program and supports site-based research for all therapeutic areas across 21 medical centers and more than 260 clinics. He is the recipient of a National Heart, Lung, and Blood Institute (NHLBI)-funded Mentored Patient-Oriented Research Career Development Award (K23HL150159) focused on identifying and characterizing outpatient worsening heart failure within an integrated and learning health care system. He is currently the Principal Investigator (PI), Co-PI, or Co-Investigator on multiple investigator-initiated and industry-sponsored traditional and pragmatic clinical trials addressing a broad range of medical topics.

Dr. Ambrosy previously completed a 2-year dedicated research fellowship at the Duke Clinical Research Institute, gaining hands-on experience in all aspects of clinical trial operations. This includes study design, site activation, recruitment/enrollment, and data and safety monitoring. He is an Associate Editor for the American Heart Journal and serves on the editorial boards for European Journal of Heart Failure and Journal of Cardiac Failure. Dr. Ambrosy has presented his research at national and international scientific meetings and authored more than 150 peer-reviewed manuscripts.

Current Positions

  • Staff Cardiologist, Department of Cardiology, The Permanente Medical Group, San Francisco
  • Research Scientist, Division of Research, Kaiser Permanente Northern California
  • Associate Program Director for Research (Fellowship), Department of Cardiology, The Permanente Medical Group, San Francisco
  • Assistant Medical Director, Clinical Trials Program, Kaiser Permanente Northern California

Section Affiliations

Primary Research Interests

  • Ischemia Heart Disease
  • Cardiomyopathy
  • Heart Failure
  • Health Outcomes
  • Implementation Science
  • Clinical Trials

Related Websites

Studies

Improving Care by Defining the Role of ElectroNic HealTh Record-Based Alerts In a Fully Integrated Health Care Delivery SYstem for Worsening Heart Failure (IDENTIFY-WHF)

IDENTIFY-WHF is a prospective, virtual, parallel-group, randomized, quality improvement intervention of EHR-based alerts for worsening heart failure (WHF) to improve the adoption of guideline-directed medical therapy (GDMT) within an integrated and learning health care delivery system. Approximately 1,000 participants will be randomized 1:1 to the intervention or usual standard of care. The primary outcome is the proportion of adults experiencing WHF with an increase in the number of prescribed GDMT classes at 30 days post-discharge from the hospital or ED.

Investigator: Ambrosy, Andrew

Funder: TPMG Delivery Science Projects Program

Trajectory of PRimary and SEcondAry HospitalizaTions for Worsening Heart Failure (TREAT-WHF)

The primary objective of the TREAT-WHF study is to leverage a diverse and contemporary heart failure cohort with rigorously adjudicated worsening heart failure events to describe the crude rate of all-cause and cause-specific health care utilization and the independent association of secondary heart failure hospitalizations with outcomes after adjusting for traditional risk factors. This study builds on our prior research that showed machine learning-based natural language processing algorithms can accurately identify hospitalizations for worsening heart failure and resulted in a more than twofold increase in the perceived population burden of hospitalizations for worsening heart failure compared to diagnostic coding alone.

Investigator: Ambrosy, Andrew

Funder: Lexicon Pharmaceuticals, Inc.

Cholesterol Lowering via Bempedoic Acid, an ACL-Inhibiting Regimen in Acute Coronary Syndrome (CLEAR ACS) Study

The overall objective of the Cholesterol Lowering via Bempedoic Acid/Ezetimibe, an ACL-Inhibiting Regimen in Acute Coronary Syndrome ACS (CLEAR ACS) study is to determine the efficacy, safety, and tolerability of bempedoic acid/ezetimibe (BA/E) in a contemporary and real-world population, enriched for older adults, women, and underrepresented racial/ethnic groups, of adults with a recent acute coronary syndrome (ACS) event independent of use of statin therapy before the ACS event. CLEAR ACS study is a prospective, virtual, electronic health record (EHR)-based, randomized, double-blind, placebo-controlled, parallel-group, pragmatic clinical trial embedded within Kaiser Permanente Northern California’s fully integrated and learning health care delivery system. 

Investigator: Ambrosy, Andrew

Funder: Esperion Therapeutics, Inc.

Clinical Characteristics and Outcomes of Patients with Asymptomatic, Moderate Severity Aortic Stenosis (ASSESS-AS)

The prevalence of aortic stenosis (AS), currently estimated to be 4% among adults 70 years of age and over is projected to double by 2040 and triple by 2060. However, the prevalence, clinical characteristics, and outcomes of the condition have not been well-characterized in a contemporary, demographically diverse cohort with asymptomatic moderate AS. We are leveraging a natural language processing (NLP)-based approach applied to state-of-the-art electronic health record semi-structured data to describe (1) the prevalence and clinical characteristics, (2) all-cause and cause-specific healthcare utilization and all-cause death, and (3) independent clinical predictors of all-cause and cause-specific morbidity and mortality among a diverse real-world cohort of asymptomatic adults with moderate AS.

Investigator: Ambrosy, Andrew

Funder: Edwards Lifesciences LLC

The Use of Natural Language Processing to Characterize Episodes of Outpatient Worsening Heart Failure within an Integrated Health Care Delivery System

This study will assess the accuracy of using a natural language processing-based approach to retrospectively identify episodes of outpatient worsening heart failure in unstructured electronic health record data within an integrated health care delivery system and assess the burden and clinical characteristics of these outpatients.

Investigator: Ambrosy, Andrew

Funder: Northern California Community Benefit Programs

Outpatient Worsening Heart Failure in an Integrated Health Care Delivery System: An Innovative Approach to Characterizing a Novel Clinical Entity

While the Affordable Care Act-mandated Hospital Readmission Reduction Program launched in 2012 has modestly reduced readmissions, an unintended consequence has been the shift of a significant fraction of heart failure (HF)-related care to the outpatient setting. However, little is known about the epidemiology, clinical profile, treatment patterns, and/or outcomes of outpatient worsening HF (WHF). To address these critical knowledge gaps, we propose (1) to systematically describe the contemporary epidemiology, clinical characteristics, treatment patterns, and outcomes associated with outpatient WHF and (2) to evaluate the impact of an episode of outpatient WHF on generic and disease-specific HRQOL in the context of a fully integrated health care delivery system.

Investigator: Ambrosy, Andrew

Funder: National Heart, Lung, and Blood Institute

Transcatheter Mitral-Valve Repair in Patients with Heart Failure and Functional Mitral Regurgitation – Potential Scope and Clinical Benefit of Early Adoption at an Integrated Healthcare Delivery System

This study will look at the clinical benefit of early adoption of the MitraClip device in patients with heart failure in a real-world setting. Previous research showed patients who have the MitraClip procedure have 50% fewer hospitalizations for heart failure within the next 24 months than those who receive the standard of care. The MitraClip is used to reduce mitral regurgitation, a common side effect of heart failure, that affects quality of life and functioning, increases risk of hospitalization, and reduces survival despite medical therapy.

Investigator: Ambrosy, Andrew

Funder: Abbott Laboratories

Evaluating Inpatient and OutpatIent Encounters Within a Learning and Integrated Health Care Delivery Organization Due to Worsening Heart Failure (UTILIZE-WHF)

This study will assess the inpatient and outpatient health care utilization and mortality of patients with heart failure and how it relates to their degree of systolic dysfunction.

Investigator: Ambrosy, Andrew

Funder: Novartis International AG

Pragmatic RandomIzed Trial of Icosapent Ethyl for High-Cadiovascular Risk Adults (MITIGATE)

The MITIGATE Study will evaluate the real-world clinical effectiveness of icosapent ethyl (Vascepa®) compared to usual care in patients with established atherosclerotic cardiovascular disease. The study will evaluate whether the drug, which is used to reduce the risk of heart disease and stroke, can also prevent or reduce the risk of complications from viral respiratory illnesses in older adults with heart disease.

Investigator: Ambrosy, Andrew

Funder: Amarin Corporation

Healthy Eating as a Means for Active Living in Heart Failure (HEAL-HF) Study

There is an unmet clinical need to better understand the impact of lifestyle choices with respect to diet and nutrition in high-risk heart failure patients who have been recently hospitalized. We will conduct a survey-based project using a combination of questionnaires to assess 4 clinically relevant domains: food access and security, dietary composition and quality, nutritional awareness and understanding, and attitudes toward nutrition-related research. The survey itself will take no more than 15 to 30 minutes to complete and will be administered via telephone to 1,000 consecutive patients recently hospitalized with a primary diagnosis of heart failure who are responsible for their own meal planning. In addition to the survey elements, outcomes of interest will include subsequent heart failure hospitalization, all-cause hospitalization, and mortality occurring within 30 days. These outcomes will be passively collected via Kaiser Permanente HealthConnect electronic health records.

Investigator: Go, Alan; Ambrosy, Andrew; Gordon, Nancy

Funder: Northern California Community Benefit Programs

Disparities in Residual Risk in Patients Receiving Statins for Primary or Secondary Prevention at an Integrated Health Care Delivery System

Patients with risk factors for or established atherosclerotic cardiovascular disease (ASCVD) remain at high risk for first-time or recurrent nonfatal and fatal events, despite guideline-directed medical therapy for primary and secondary prevention. In fact, even among patients who are appropriately treated with lipid-lowering therapies and have an LDL-C that is at goal and in line with current guideline recommendations, substantial residual risk persists. There is now a considerable body of evidence to suggest that plasma triglycerides contribute to residual risk and play a causal role in atherogenesis and ASCVD risk. Furthermore, older adults, women, and nonwhite participants may have a disproportionately different prevalence of elevated triglyceride levels and be at incrementally greater risk of recurrent ASCVD events. Given the public health implications, it is important to better understand the extent of age-, gender-, and ethnicity/race-related disparities in residual risk.

Investigator: Ambrosy, Andrew

Funder: Amarin Corporation

TRANSFORM-HF (ToRsemide compArisoN with furoSemide FOR Management of Heart Failure) Study

Patients with heart failure will be randomized 1:1 to either oral torsemide or oral furosemide prior to hospital discharge. The primary endpoint will be all-cause mortality over the follow-up period. Secondary endpoints are hospitalizations, quality of life, and depression.

Investigator: Ambrosy, Andrew

Funder: National Heart, Lung, and Blood Institute

Publications

Equity in Heart Failure Care: A Get With the Guidelines Analysis of Between- and Within-Hospital Differences in Care by Sex, Race, Ethnicity, and Insurance

Authors: Sandhu, Alexander T;Ambrosy, Andrew P;Heidenreich, Paul A;et al.

Circ Heart Fail. 2024 Oct;17(10):e011177. Epub 2024-09-18.

PubMed abstract

Modulating energy metabolism to treat non-obstructive hypertrophic cardiomyopathy? Insights from IMPROVE-HCM

Authors: Beghini, Alberto;Aimo, Alberto;Ambrosy, Andrew P;Tomasoni, Daniela

Heart Fail Rev. 2024 Sep 23.

PubMed abstract

Rule-based natural language processing to examine variation in worsening heart failure hospitalizations by age, sex, race and ethnicity, and left ventricular ejection fraction

Authors: Mefford, Matthew T;Ambrosy, Andrew P;Wei, Rong;Zheng, Chengyi;Parikh, Rishi V;Harrison, Teresa N;Lee, Ming-Sum;Go, Alan S;Reynolds, Kristi

Am Heart J. 2024 Sep 07.

PubMed abstract

Mineralocorticoid Antagonism in Heart Failure: Established and Emerging Therapeutic Role

Authors: Chang, Joycie;Ambrosy, Andrew P;Vardeny, Orly;Van Spall, Harriette G C;Mentz, Robert J;Sauer, Andrew J

JACC Heart Fail. 2024 Sep 01.

PubMed abstract

Polypharmacy and Guideline-Directed Medical Therapy Initiation Among Adults Hospitalized With Heart Failure

Authors: Onyebeke, Chukwuma;Zhang, David;Musse, Mahad;Unlu, Ozan;Nahid, Musarrat;Ambrosy, Andrew P;Levitan, Emily B;Safford, Monika M;Goyal, Parag

JACC Adv. 2024 Sep;3(9):101126. Epub 2024-08-05.

PubMed abstract

Selective aldose reductase inhibition as a treatment for diabetic cardiomyopathy: summary of the ARISE-HF trial

Authors: Khan, Laibah Arshad;Khan, Muhammad Shahzeb;Ambrosy, Andrew P;Greene, Stephen J

Heart Fail Rev. 2024 Sep;29(5):1157-1160. Epub 2024-07-25.

PubMed abstract

Inpatient Use of Guideline-Directed Medical Therapy During Heart Failure Hospitalizations Among Community-Based Health Systems

Authors: Zheng, Jimmy;Bhatt, Ankeet S;Ambrosy, Andrew P;Ambrosy, Andrew P;et al.

JACC Heart Fail. 2024 Aug 30.

PubMed abstract

Characteristics, treatment, and outcomes of early vs. late enrollees of the STRONG-HF trial

Authors: Arrigo, Mattia;Ambrosy, Andrew P;Mebazaa, Alexandre;et al.

Am Heart J. 2024 Aug;274:119-129. Epub 2024-05-12.

PubMed abstract

Biologically active adrenomedullin as a marker for residual congestion and early rehospitalization in patients hospitalized for acute heart failure: Data from STRONG-HF

Authors: Voordes, Geert;Ambrosy, Andrew P;Voors, Adriaan A;et al.

Eur J Heart Fail. 2024 Jun 14.

PubMed abstract

Equity in the Setting of Heart Failure Diagnosis: An Analysis of Differences Between and Within Clinician Practices

Authors: Gupta, Anshal;Tisdale, Rebecca L;Calma, Jamie;Stafford, Randall S;Maron, David J;Hernandez-Boussard, Tina;Ambrosy, Andrew P;Heidenreich, Paul A;Sandhu, Alexander T

Circ Heart Fail. 2024 Jun;17(6):e010718. Epub 2024-06-07.

PubMed abstract

On-treatment analysis of torsemide versus furosemide for patients hospitalized for heart failure: A post-hoc analysis of TRANSFORM-HF

Authors: Kittipibul, Veraprapas;Ambrosy, Andrew P;Greene, Stephen J;et al.

Eur J Heart Fail. 2024 May 15.

PubMed abstract

Applying natural language processing to identify emergency department and observation encounters for worsening heart failure

Authors: Hamilton, Steven A;Ambrosy, Andrew P;Parikh, Rishi V;Tan, Thida C;Fitzpatrick, Jesse K;Avula, Harshith R;Sandhu, Alexander T;Ku, Ivy A;Go, Alan S;Sax, Dana;Bhatt, Ankeet S

ESC Heart Fail. 2024 May 13.

PubMed abstract

Titration of Medications After Acute Heart Failure Is Safe, Tolerated, and Effective Regardless of Risk

Authors: Ambrosy, Andrew P;Mebazaa, Alexandre;et al.

JACC Heart Fail. 2024 May 12.

PubMed abstract

Medical Decision-Making and Revascularization in Ischemic Cardiomyopathy

Authors: Chang, Alex J;Liang, Yilin;Hamilton, Steven A;Ambrosy, Andrew P

Med Clin North Am. 2024 May;108(3):553-566. Epub 2023-12-18.

PubMed abstract

Sex-Based Differences in the Epidemiology, Clinical Characteristics, and Outcomes Associated with Worsening Heart Failure Events in a Learning Health System

Authors: Leung, Chloe J;Go, Alan S;Sax, Dana R;Ambrosy, Andrew P;Ambrosy, Andrew P;et al.

J Card Fail. 2024 Apr 30.

PubMed abstract

Contemporary Decongestion Strategies in Patients Hospitalized for Heart Failure: A National Community-Based Cohort Study

Authors: Zheng, Jimmy;Bhatt, Ankeet S;Sandhu, Alexander T;et al.

JACC Heart Fail. 2024 Apr 07.

PubMed abstract

Follow the EMPULSE: In-hospital initiation of empagliflozin for heart failure across the spectrum of left ventricular ejection fraction

Authors: Lien, Tann;Srikanth, Kishan;Ambrosy, Andrew P

Eur J Heart Fail. 2024 Apr;26(4):971-973. Epub 2024-04-23.

PubMed abstract

Initial antiretroviral therapy regimen and risk of heart failure

Authors: Silverberg, Michael J;Ambrosy, Andrew P;Go, Alan S;Neugebauer, Romain;Neugebauer, Romain;et al.

AIDS. 2024 Mar 15;38(4):547-556. Epub 2023-11-14.

PubMed abstract

Eligibility and Potential Benefit of Transcatheter Edge-to-Edge Repair in a Contemporary Cohort With Heart Failure: Evidence From a Large Integrated Health Care Delivery System

Authors: Ambrosy, Andrew P;Bhatt, Ankeet S;Solomon, Matthew D;Zaroff, Jonathan G;Go, Alan S;Go, Alan S;et al.

Struct Heart. 2024 Mar;8(2):100237. Epub 2023-12-19.

PubMed abstract

Acetazolamide as an Adjunctive Diuretic Therapy for Patients with Acute Decompensated Heart Failure: A Systematic Review and Meta-Analysis

Authors: Siddiqi, Ahmed Kamal;Maniya, Muhammad Talha;Alam, Muhammad Tanveer;Ambrosy, Andrew P;Fudim, Marat;Greene, Stephen J;Khan, Muhammad Shahzeb

Am J Cardiovasc Drugs. 2024 Mar;24(2):273-284. Epub 2024-02-28.

PubMed abstract

Settling the IRONy of Anemia in Heart Failure: Current Evidence and Future Directions

Authors: Tsangaris, Adamantios;Ambrosy, Andrew P;Tschida, Michael;Alexy, Tamas

J Card Fail. 2024 Feb 22.

PubMed abstract

A PACT for the future: Improving medication adherence in heart failure

Authors: Min, Kyung H;Jackson, Stephanie A;Ambrosy, Andrew P

Eur J Heart Fail. 2024 Feb 12.

PubMed abstract

Uptake of sodium-glucose cotransporter-2 inhibitors in hospitalized patients with heart failure: insights from the veterans affairs healthcare system

Authors: Varshney, Anubodh S;Bhatt, Ankeet S;Ambrosy, Andrew P;Sandhu, Alexander T;et al.

J Card Fail. 2024 Jan 26.

PubMed abstract

In Search of a Timely, Safe, and Effective Alternative to Hospitalization for Heart Failure

Authors: Gustafson, Shanshan E;Hamilton, Steven A;Ambrosy, Andrew P

JAMA Netw Open. 2024 Jan 02;7(1):e2350454. Epub 2024-01-02.

PubMed abstract

Effective medications can work only in patients who take them: implications for post acute heart failure care

Authors: Cotter, Gad;Ambrosy, Andrew P;Bhatt, Ankeet S;Bhatt, Deepak L;et al.

Eur J Heart Fail. 2024 Jan;26(1):1-4. Epub 2024-01-08.

PubMed abstract

Developing Clinical Risk Prediction Models for Worsening Heart Failure Events and Death by Left Ventricular Ejection Fraction

Authors: Parikh, Rishi V;Bhatt, Ankeet S;Lee, Keane K;Sax, Dana R;Ambrosy, Andrew P;Ambrosy, Andrew P;et al.

J Am Heart Assoc. 2023 Oct 03;12(19):e029736. Epub 2023-09-30.

PubMed abstract

Physician Assessment of Aortic Stenosis Severity, Quantitative Parameters, and Long-Term Outcomes: Results from the KP-VALVE Project

Authors: Solomon, Matthew D;Lange, David C;Ambrosy, Andrew P;Krishnaswami, Ashok;Nishimura, Rick;Go, Alan S;et al.

Am Heart J. 2023 Aug 06.

PubMed abstract

Temporal trends in the prevalence and severity of aortic stenosis within a contemporary and diverse community-based cohort

Authors: Ambrosy, Andrew P;Berry, Natalia;Solomon, Matthew D;et al.

Int J Cardiol. 2023 Aug 01;384:107-111. Epub 2023-04-27.

PubMed abstract

Acetazolamide as a decongestion strategy in acute decompensated heart failure: Balancing fluid removal and electrolyte disturbances

Authors: Butte, Zara;Ambrosy, Andrew P

Eur J Heart Fail. 2023 Aug;25(8):1320-1322. Epub 2023-06-27.

PubMed abstract

Special DELIVERy: reducing high-complexity hospitalizations in heart failure

Authors: Gustafson, Shanshan E;Ambrosy, Andrew P;Bhatt, Ankeet S

Eur J Heart Fail. 2023 Aug;25(8):1372-1374. Epub 2023-07-11.

PubMed abstract

Understanding cardiohepatic interactions in patients with heart failure with mildly reduced or preserved ejection fraction

Authors: Chang, Alex J;Bhatt, Ankeet S;Ambrosy, Andrew P

Eur J Heart Fail. 2023 Aug;25(8):1384-1385. Epub 2023-07-10.

PubMed abstract

Incidence, Predictors, and Outcomes Associated With Worsening Renal Function in Patients With Heart Failure and Secondary Mitral Regurgitation: The COAPT Trial

Authors: Kong, Jeremy;Zaroff, Jonathan G;Stone, Gregg W;et al.

J Am Heart Assoc. 2023 Jul 18;12(14):e029504. Epub 2023-07-08.

PubMed abstract

Effect of Torsemide vs Furosemide on Symptoms and Quality of Life Among Patients Hospitalized for Heart Failure: The TRANSFORM-HF Randomized Clinical Trial

Authors: Greene, Stephen J;Psotka, Mitchell A;TRANSFORM-HF Investigators,;et al.

Circulation. 2023 Jul 11;148(2):124-134. Epub 2023-05-22.

PubMed abstract

Iron Deficiency in Heart Failure: A Scientific Statement from the Heart Failure Society of America

Authors: Beavers, Craig J;Ambrosy, Andrew P;Butler, Javed;Davidson, Beth T;Gale, Stormi E;Piña, Ileana L;Mastoris, Ioannis;Reza, Nosheen;Mentz, Robert J;Lewis, Gregory D

J Card Fail. 2023 Jul;29(7):1059-1077. Epub 2023-05-01.

PubMed abstract

Outcomes of Adults with Severe Aortic Stenosis Undergoing Urgent or Emergent vs. Elective Transcatheter Aortic Valve Replacement Within an Integrated Health Care Delivery System

Authors: Slade, Justin J;Ku, Ivy A;Philip, Femi;Mishell, Jacob M;et al.

Struct Heart. 2023 Jul;7(4):100166. Epub 2023-03-21.

PubMed abstract

The association between changes in echocardiography and risk of heart failure hospitalizations and death in adults with chronic kidney disease

Authors: Fitzpatrick, Jesse K;Parikh, Rishi V;Hamilton, Steven A;Ambrosy, Andrew P;Tan, Thida C;Bansal, Nisha;Go, Alan S;CRIC Study Investigators,

Sci Rep. 2023 May 31;13(1):8863. Epub 2023-05-31.

PubMed abstract

Association Between Participation in a Heart Failure Telemonitoring Program and Healthcare Utilization and Death within an Integrated Health Care Delivery System

Authors: Parikh, Rishi V;Axelrod, Amir W;Ambrosy, Andrew P;Tan, Thida C;Bhatt, Ankeet S;Fitzpatrick, Jesse K;Lee, Keane K;Aditya, Sirtaz;Vasadia, Jitesh V;Dinh, Howard H;Go, Alan S

J Card Fail. 2023 May 21.

PubMed abstract

Polypharmacy and Optimization of Guideline-Directed Medical Therapy in Heart Failure: The GUIDE-IT Trial

Authors: Khan, Muhammad Shahzeb;Keshvani, Neil;Pandey, Ambarish;et al.

JACC Heart Fail. 2023 Apr 15.

PubMed abstract

Intravenous iron infusion in patients with heart failure: a systematic review and study-level meta-analysis

Authors: Salah, Husam M; Savarese, Gianluigi; Rosano, Giuseppe M C; Ambrosy, Andrew P; Mentz, Robert J; Fudim, Marat

ESC Heart Fail. 2023 Apr;10(2):1473-1480. Epub 2023-02-02.

PubMed abstract

Association Between Serum Albumin and Outcomes in Heart Failure and Secondary Mitral Regurgitation: The COAPT Trial

Authors: Feng, Kent Y; Ambrosy, Andrew P; Zaroff, Jonathan G; COAPT trial investigators,; et al.

Eur J Heart Fail. 2023 Apr;25(4):553-561. Epub 2023-03-07.

PubMed abstract

Predictors of Incident Heart Failure Diagnosis Setting: Insights From the Veterans Affairs Healthcare System

Authors: Tisdale, Rebecca L; Fan, Jun; Calma, Jamie; Cyr, Kevin; Podchiyska, Tanya; Stafford, Randall S; Maron, David J; Hernandez-Boussard, Tina; Ambrosy, Andrew; Heidenreich, Paul A; Sandhu, Alexander T

JACC Heart Fail. 2023 Mar;11(3):347-358. Epub 2023-02-01.

PubMed abstract

Predicting Short-term Outcomes After Transcatheter Aortic Valve Replacement for Aortic Stenosis

Authors: Savitz, Samuel T; Leong, Thomas; Sung, Sue Hee; Kitzman, Dalane W; McNulty, Edward; Mishell, Jacob; Rassi, Andrew; Ambrosy, Andrew P; Go, Alan S

Am Heart J. 2023 Feb;256:60-72. Epub 2022-11-11.

PubMed abstract

Heart failure during the COVID-19 pandemic: clinical, diagnostic, management, and organizational dilemmas

Authors: Palazzuoli, Alberto; Ambrosy, Andrew P; Chioncel, Ovidiu; et al.

ESC Heart Fail. 2022 Dec;9(6):3713-3736. Epub 2022-09-16.

PubMed abstract

Characteristics and Outcomes of Suspected Digoxin Toxicity and Immune Fab Treatment Over the Past Two Decades-2000-2020

Authors: Peters, Anthony E; Chiswell, Karen; Hofmann, Paul; Ambrosy, Andrew; Fudim, Marat

Am J Cardiol. 2022 Nov 15;183:129-136. Epub 2022-09-09.

PubMed abstract

Variation in Heart Failure Risk by HIV Severity and Sex in People With HIV Infection

Authors: Lam, Jennifer O; Ambrosy, Andrew P; Go, Alan S; Silverberg, Michael J; et al.

J Acquir Immune Defic Syndr. 2022 Oct 01;91(2):175-181.

PubMed abstract

Fluid Restriction Recommendations in Heart Failure Dry as a Bone or Quench Your Thirst?

Authors: Merlo, Aurelie; Mezue, Kenechukwu; Ambrosy, Andrew P

J Card Fail. 2022 10;28(10):1531-1533. Epub 2022-08-15.

PubMed abstract

Effect of Medically Tailored Meals on Clinical Outcomes in Recently Hospitalized High-Risk Adults

Authors: Go, Alan S; Ambrosy, Andrew P; Lee, Keane K; Lo, Joan C; KP NOURISH Study Investigators,; et al.

Med Care. 2022 Oct 01;60(10):750-758. Epub 2022-08-15.

PubMed abstract

Heart Failure with Iron Deficiency across the Left Ventricular Ejection Fraction Continuum – Need to Redefine?

Authors: Sawicki, Konrad Teodor; Ambrosy, Andrew P

J Card Fail. 2022 08;28(8):1264-1266. Epub 2022-02-11.

PubMed abstract

Analysis of Worsening Heart Failure Events in an Integrated Health Care System

Authors: Ambrosy, Andrew P; Go, Alan S; et al.

J Am Coll Cardiol. 2022 Jul 12;80(2):111-122.

PubMed abstract

Long-Term Cardiovascular Effects of COVID-19: Emerging Data Relevant to the Cardiovascular Clinician

Authors: Tobler, Diana L; Pruzansky, Alix J; Naderi, Sahar; Ambrosy, Andrew P; Slade, Justin J

Curr Atheroscler Rep. 2022 07;24(7):563-570. Epub 2022-05-04.

PubMed abstract

Prognostic Value of Echocardiography for Heart Failure and Death in Adults with Chronic Kidney Disease

Authors: Fitzpatrick, Jesse K; Ambrosy, Andrew P; Parikh, Rishi V; Tan, Thida C; Bansal, Nisha; Go, Alan S; CRIC Study Investigators,,

Am Heart J. 2022 06;248:84-96. Epub 2022-03-10.

PubMed abstract

A Randomized Controlled Trial of Renin-Angiotensin-Aldosterone System Inhibitor Management in Patients Admitted in Hospital with COVID-19

Authors: Sharma, Abhinav; Ambrosy, Andrew P; Ferreira, João Pedro; et al.

Am Heart J. 2022 05;247:76-89. Epub 2022-02-07.

PubMed abstract

Trends and characteristics of hospitalizations for heart failure in the United States from 2004 to 2018

Authors: Salah, Husam M; Minhas, Abdul Mannan Khan; Khan, Muhammad Shahzeb; Khan, Safi U; Ambrosy, Andrew P; Blumer, Vanessa; Vaduganathan, Muthiah; Greene, Stephen J; Pandey, Ambarish; Fudim, Marat

ESC Heart Fail. 2022 04;9(2):947-952. Epub 2022-01-30.

PubMed abstract

Global assessment improves risk stratification for major adverse cardiac events across a wide range of triglyceride levels: Insights from the KP REACH study

Authors: Wagner, Jeffrey R; Fitzpatrick, Jesse K; Yang, Jingrong; Sung, Sue Hee; Allen, Amanda R; Philip, Sephy; Granowitz, Craig; Abrahamson, David; Ambrosy, Andrew P; Go, Alan S

Am J Prev Cardiol. 2022 Mar;9:100319. Epub 2022-01-29.

PubMed abstract

Food security, diet quality, nutritional knowledge, and attitudes towards research in adults with heart failure during the COVID-19 pandemic

Authors: Ambrosy, Andrew P; Malik, Umar I; Leong, Thomas K; Allen, Amanda R; Sung, Sue Hee; Go, Alan S; Healthy Eating as a Means for Active Living in Heart Failure (HEAL-HF) Study,

Clin Cardiol. 2022 Feb;45(2):180-188. Epub 2022-02-02.

PubMed abstract

A Machine Learning Methodology for Identification and Triage of Heart Failure Exacerbations

Authors: Morrill, James; Qirko, Klajdi; Kelly, Jacob; Ambrosy, Andrew; Toro, Botros; Smith, Ted; Wysham, Nicholas; Fudim, Marat; Swaminathan, Sumanth

J Cardiovasc Transl Res. 2022 02;15(1):103-115. Epub 2021-08-28.

PubMed abstract

Loop and thiazide diuretic use and risk of chronic kidney disease progression: a multicentre observational cohort study

Authors: Fitzpatrick, Jesse K; Yang, Jingrong; Ambrosy, Andrew P; Cabrera, Claudia; Stefansson, Bergur V; Greasley, Peter J; Patel, Jignesh; Tan, Thida C; Go, Alan S

BMJ Open. 2022 01 31;12(1):e048755. Epub 2022-01-31.

PubMed abstract

Trends in Hospitalizations for Heart Failure, Acute Myocardial Infarction, and Stroke in the United States from 2004-2018

Authors: Salah, Husam M; Khan Minhas, Abdul Mannan; Khan, Muhammad Shahzeb; Khan, Safi U; Ambrosy, Andrew P; Blumer, Vanessa; Vaduganathan, Muthiah; Greene, Stephen J; Pandey, Ambarish; Fudim, Marat

Am Heart J. 2022 01;243:103-109. Epub 2021-09-25.

PubMed abstract

Antithrombotic and anticoagulation therapies in cardiogenic shock: a critical review of the published literature

Authors: Radu, Razvan I; Ambrosy, Andrew P; Chioncel, Ovidiu; et al.

ESC Heart Fail. 2021 12;8(6):4717-4736. Epub 2021-10-19.

PubMed abstract

Human immunodeficiency virus infection and risks of morbidity and death in adults with incident heart failure

Authors: Avula, Harshith R; Ambrosy, Andrew P; Silverberg, Michael J; Lee, Keane K; Go, Alan S; et al.

Eur Heart J Open. 2021 Nov;1(3):oeab040. Epub 2021-12-01.

PubMed abstract

A Natural Language Processing-Based Approach for Identifying Hospitalizations for Worsening Heart Failure Within an Integrated Health Care Delivery System

Authors: Ambrosy, Andrew P; Go, Alan S; et al.

JAMA Netw Open. 2021 11 01;4(11):e2135152. Epub 2021-11-01.

PubMed abstract

Triglyceride Levels and Residual Risk of Atherosclerotic Cardiovascular Disease Events and Death in Adults Receiving Statin Therapy for Primary or Secondary Prevention: Insights From the KP REACH Study

Authors: Ambrosy, Andrew P; Yang, Jingrong; Sung, Sue Hee; Allen, Amanda R; Fitzpatrick, Jesse K; Rana, Jamal S; Wagner, Jeffrey; Philip, Sephy; Abrahamson, David; Granowitz, Craig; Go, Alan S

J Am Heart Assoc. 2021 10 19;10(20):e020377. Epub 2021-10-08.

PubMed abstract

Timing of AKI after urgent percutaneous coronary intervention and clinical outcomes: a high-dimensional propensity score analysis

Authors: Go, Alan S; Tan, Thida C; Parikh, Rishi V; Ambrosy, Andrew P; Pravoverov, Leonid V; Zheng, Sijie; Leong, Thomas K

BMC Nephrol. 2021 09 06;22(1):300. Epub 2021-09-06.

PubMed abstract

Implications of the Landmark ISCHEMIA Trial on the Initial Management of High-Risk Patients with Stable Ischemic Heart Disease

Authors: Vafaei, Paniz; Naderi, Sahar; Ambrosy, Andrew P; Slade, Justin J

Curr Atheroscler Rep. 2021 09 01;23(11):70. Epub 2021-09-01.

PubMed abstract

A Randomized Trial of Icosapent Ethyl in Ambulatory Patients with COVID-19

Authors: Kosmopoulos, Andrew; Go, Alan S; Ambrosy, Andrew P; Mazer, C David; et al.

iScience. 2021 Aug 26:103040.

PubMed abstract

Safety and Efficacy of Intravenous Ferric Derisomaltose Compared to Iron Sucrose for Iron Deficiency Anemia in Patients with Chronic Kidney Disease With and Without Heart Failure

Authors: Ambrosy, Andrew P; von Haehling, Stephan; Kalra, Paul R; Court, Emma; Bhandari, Sunil; McDonagh, Theresa; Cleland, John G F

Am J Cardiol. 2021 08 01;152:138-145. Epub 2021-06-20.

PubMed abstract

Growth differentiation factor-15, treatment with liraglutide, and clinical outcomes among patients with heart failure

Authors: Sharma, Abhinav; Ambrosy, Andrew P; Felker, G Michael; et al.

ESC Heart Fail. 2021 08;8(4):2608-2616. Epub 2021-06-01.

PubMed abstract

Pregnancy-Associated Spontaneous Coronary Artery Dissection: Clinical Characteristics, Outcomes, and Risk During Subsequent Pregnancy

Authors: Chen, Stephanie; Merchant, Maqdooda; Mahrer, Kenneth N; Ambrosy, Andrew P; Lundstrom, Robert J; Naderi, Sahar

J Invasive Cardiol. 2021 06;33(6):E457-E466. Epub 2021-05-14.

PubMed abstract

Making The Case For Sacubitril/Valsartan In Patients With Heart Failure With A Preserved Ejection Fraction

Authors: Tai, Andrew; Ambrosy, Andrew P; Fudim, Marat

Eur Heart J Cardiovasc Pharmacother. 2021 05 23;7(3):e5-e6.

PubMed abstract

Randomized Placebo-Controlled Trial of Ferric Carboxymaltose in Heart Failure With Iron Deficiency: Rationale and Design

Authors: Mentz, Robert J; Ambrosy, Andrew P; HEART-FID Trial Investigators,; et al.

Circ Heart Fail. 2021 05;14(5):e008100. Epub 2021-05-18.

PubMed abstract

Rationale and Design of the Pragmatic Randomized Trial of Icosapent Ethyl for High Cardiovascular Risk Adults (MITIGATE)

Authors: Ambrosy, Andrew P; Solomon, Matthew D; Skarbinski, Jacek; Go, Alan S; et al.

Am Heart J. 2021 05;235:54-64. Epub 2021-01-28.

PubMed abstract

Improving adherence to guideline-directed medical therapies and outcomes in the developing world: A call to end global inequities in heart failure

Authors: Chioncel, Ovidiu; Ambrosy, Andrew P

Int J Cardiol. 2021 04 15;329:74-76. Epub 2020-12-02.

PubMed abstract

Temporal trends in the outcomes of acute heart failure: between consolatory evidences and real progress

Authors: Chioncel, Ovidiu; Ambrosy, Andrew P; Maggioni, Aldo P

Eur J Heart Fail. 2021 03;23(3):432-435. Epub 2021-02-26.

PubMed abstract

Management of Renin-Angiotensin-Aldosterone System blockade in patients admitted to hospital with confirmed coronavirus disease (COVID-19) infection (The McGill RAAS-COVID- 19): A structured summary of a study protocol for a randomized controlled trial

Authors: Aflaki, Mona; Ambrosy, Andrew P; Sharma, Abhinav; et al.

Trials. 2021 Feb 05;22(1):115. Epub 2021-02-05.

PubMed abstract

Loop Diuretic Use and Outcomes in Chronic Stable Heart Failure With Preserved Ejection Fraction-Reply

Authors: Rao, Vishal N; Pandey, Ambarish; Zhong, Lin; Ambrosy, Andrew P; Fudim, Marat

Mayo Clin Proc. 2021 02;96(2):503-506.

PubMed abstract

Implications of peripheral oedema in heart failure with preserved ejection fraction: a heart failure network analysis

Authors: Fudim, Marat; Ambrosy, Andrew P; Mentz, Robert J; et al.

ESC Heart Fail. 2021 02;8(1):662-669. Epub 2020-12-09.

PubMed abstract

The Degree of the Predischarge Pulmonary Congestion in Patients Hospitalized for Worsening Heart Failure Predicts Readmission and Mortality

Authors: Kleiner-Shochat, Michael; Kapustin, Daniel; Fudim, Marat; Ambrosy, Andrew P; Glantz, Juliya; Kazatsker, Mark; Kleiner, Ilia; Weinstein, Jean Marc; Panjrath, Gurusher; Roguin, Ariel; Meisel, Simcha R

Cardiology. 2021;146(1):49-59. Epub 2020-10-28.

PubMed abstract

Hospitalizations for Heart Failure and Mortality Risk During the Evolving Coronavirus Disease 2019 Pandemic – The Wave May Break but A Dangerous Undertow Persists

Authors: Wagner, Jeffrey R; Ambrosy, Andrew P

Eur J Heart Fail. 2020 12;22(12):2225-2227. Epub 2020-11-16.

PubMed abstract

Baseline Functional Capacity and Transcatheter Mitral Valve Repair in Heart Failure With Secondary Mitral Regurgitation

Authors: Malik, Umar I; Ambrosy, Andrew P; Stone, Gregg W; et al.

JACC Cardiovasc Interv. 2020 10 26;13(20):2331-2341.

PubMed abstract

Angiotensin-Neprilysin Inhibition in Black Americans: Data From the PIONEER-HF Trial

Authors: Berardi, Cecilia; Braunwald, Eugene; Morrow, David A; Mulder, Hillary S; Duffy, Carol I; O'Brien, Terrence X; Ambrosy, Andrew P; Chakraborty, Hrishikesh; Velazquez, Eric J; DeVore, Adam D; PIONEER-HF Investigators,

JACC Heart Fail. 2020 10;8(10):859-866. Epub 2020-09-09.

PubMed abstract

Hospitalizations for heart failure during the COVID-19 pandemic: making sense of the known knowns, known unknowns, and unknown unknowns

Authors: Ambrosy, Andrew P; Fitzpatrick, Jesse K; Fudim, Marat

Eur J Heart Fail. 2020 10;22(10):1752-1754. Epub 2020-08-04.

PubMed abstract

Sacubitril/Valsartan in Advanced Heart Failure With Reduced Ejection Fraction: Rationale and Design of the LIFE Trial

Authors: Mann DL; Ambrosy AP; LIFE Investigators; et al.

JACC Heart Fail. 2020 10;8(10):789-799. Epub 2020-06-10.

PubMed abstract

Angiotensin Receptor-Neprilysin Inhibition Based on History of Heart Failure and Use of Renin-Angiotensin System Antagonists

Authors: Ambrosy, Andrew P; Braunwald, Eugene; Morrow, David A; DeVore, Adam D; McCague, Kevin; Meng, Xiangyi; Duffy, Carol I; Rocha, Ricardo; Velazquez, Eric J; PIONEER-HF Investigators,

J Am Coll Cardiol. 2020 09 01;76(9):1034-1048.

PubMed abstract

Improving Physical Activity and Exercise Capacity in Heart Failure Taking the First Step is Always the Hardest

Authors: Ambrosy AP; Chioncel O

Eur J Heart Fail. 2020 09;22(9):1734-1736. Epub 2020-07-15.

PubMed abstract

The Covid-19 Pandemic and the Incidence of Acute Myocardial Infarction

Authors: Solomon MD; McNulty EJ; Rana JS; Leong TK; Lee C; Sung SH; Ambrosy AP; Sidney S; Go AS

N Engl J Med. 2020 08 13;383(7):691-693. Epub 2020-05-19.

PubMed abstract

Association between systolic ejection time and outcomes in heart failure by ejection fraction

Authors: Patel PA; Ambrosy AP; Phelan M; Alenezi F; Chiswell K; Van Dyke MK; Tomfohr J; Honarpour N; Velazquez EJ

Eur J Heart Fail. 2020 07;22(7):1174-1182. Epub 2019-12-21.

PubMed abstract

A reduced transferrin saturation is independently associated with excess morbidity and mortality in older adults with heart failure and incident anemia

Authors: Ambrosy AP; Go AS; RBC HEART Investigators/PACTTE Consortium; et al.

Int J Cardiol. 2020 06 15;309:95-99. Epub 2020-03-12.

PubMed abstract

Periprocedural Risk and Survival Associated With Implantable Cardioverter-Defibrillator Placement in Older Patients With Advanced Heart Failure

Authors: Fudim M; Ali-Ahmed F; Parzynski CS; Ambrosy AP; Friedman DJ; Pokorney SD; Curtis JP; Fonarow GC; Masoudi FA; Hernandez AF; Al-Khatib SM

JAMA Cardiol. 2020 06 01;5(6):643-651.

PubMed abstract

Effects of Liraglutide on Worsening Renal Function Among Patients With Heart Failure With Reduced Ejection Fraction: Insights From the FIGHT Trial

Authors: Redouane B; Ambrosy AP; Sharma A; et al.

Circ Heart Fail. 2020 05;13(5):e006758. Epub 2020-05-04.

PubMed abstract

One-year mortality after implantable cardioverter-defibrillator placement within the Veterans Affairs Health System

Authors: Fudim M; Carlisle MA; Devaraj S; Ajam T; Ambrosy AP; Pokorney SD; Al-Khatib SM; Kamalesh M

Eur J Heart Fail. 2020 05;22(5):859-867. Epub 2020-02-28.

PubMed abstract

Spontaneous Coronary Artery Dissection and Incident Ventricular Arrhythmias: Frequency, Clinical Characteristics, and Outcomes

Authors: Chen S; Ambrosy AP; Mahrer KN; Lundstrom RJ; Naderi S

JACC Cardiovasc Interv. 2020 02 24;13(4):539-541.

PubMed abstract

Statin Therapy and Risk of Incident Diabetes Mellitus in Adults With Cardiovascular Risk Factors

Authors: Go AS; Ambrosy AP; Kheder K; Fan D; Sung SH; Inveiss AI; Romo-LeTourneau V; Thomas SM; Koren A; Lo JC; Kaiser Permanente Cholesterol-Lowering Therapy in High-Risk Adults: Management and Patient Risks (KP CHAMP) Study

Am J Cardiol. 2020 02 15;125(4):534-541. Epub 2019-11-19.

PubMed abstract

Risk of atherosclerotic cardiovascular disease by cardiovascular health metric categories in approximately 1 million patients

Authors: Rana JS; Liu JY; Moffet HH; Karter AJ; Nasir K; Solomon MD; Jaffe MG; Ambrosy AP; Go AS; Sidney S

Eur J Prev Cardiol. 2020 Feb 10:2047487320905025.

PubMed abstract

Risk of atherosclerotic cardiovascular disease by cardiovascular health metric categories in approximately 1 million patients

Authors: Rana, Jamal S; Liu, Jennifer Y; Moffet, Howard H; Karter, Andrew J; Nasir, Khurram; Solomon, Matthew D; Jaffe, Marc G; Ambrosy, Andrew P; Go, Alan S; Sidney, Stephen

Eur J Prev Cardiol. 2020 Feb 07.

PubMed abstract

Initiation of Angiotensin-Neprilysin Inhibition After Acute Decompensated Heart Failure: Secondary Analysis of the Open-label Extension of the PIONEER-HF Trial

Authors: DeVore AD; Braunwald E; Morrow DA; Duffy CI; Ambrosy AP; Chakraborty H; McCague K; Rocha R; Velazquez EJ; PIONEER-HF Investigators

JAMA Cardiol. 2020 02 01;5(2):202-207.

PubMed abstract

Are existing and emerging biomarkers associated with cardiorespiratory fitness in patients with chronic heart failure?

Authors: Fudim M; Ambrosy AP; Felker GM; et al.

Am Heart J. 2020 02;220:97-107. Epub 2019-11-16.

PubMed abstract

Hyperglycemia and outcomes in acute heart failure – A bittersweet relationship

Authors: Chioncel O; Ambrosy AP

Int J Cardiol. 2020 02 01;300:196-197. Epub 2019-11-18.

PubMed abstract

Association Between Aging of the US Population and Heart Disease Mortality From 2011 to 2017

Authors: Sidney S; Go AS; Jaffe MG; Solomon MD; Ambrosy AP; Rana JS

JAMA Cardiol. 2019 12 01;4(12):1280-1286.

PubMed abstract

Haemoconcentration during treatment of acute heart failure with cardiorenal syndrome: from the CARRESS-HF trial

Authors: Blumer V; Ambrosy AP; Mentz RJ; et al.

Eur J Heart Fail. 2019 11;21(11):1472-1476. Epub 2019-08-27.

PubMed abstract

Should providers prescribe sacubitril/valsartan based on trial eligibility, approval indication, or guideline recommendations?

Authors: Ambrosy AP; Fudim M; Chioncel O

Eur J Heart Fail. 2019 11;21(11):1398-1401. Epub 2019-07-22.

PubMed abstract

Incident Anemia in Older Adults with Heart Failure Rate, Etiology, and Association with Outcomes

Authors: Ambrosy AP; Go AS; RBC HEART Investigators; et al.

Eur Heart J Qual Care Clin Outcomes. 2019 10 01;5(4):361-369.

PubMed abstract

Spironolactone in Acute Heart Failure Patients With Renal Dysfunction and Risk Factors for Diuretic Resistance: From the ATHENA-HF Trial

Authors: Greene, Stephen J; Ambrosy, Andrew P; Butler, Javed; et al.

Can J Cardiol. 2019 09;35(9):1097-1105. Epub 2019-02-07.

PubMed abstract

A Balancing Act: Preserving Renal Function and the Need for Decongestion

Authors: Fudim M; Ambrosy AP

J Card Fail. 2019 08;25(8):643-644. Epub 2019-06-26.

PubMed abstract

In-hospital initiation of sacubitril/valsartan in acute decompensated heart failure: being in the right place at the right time

Authors: Ambrosy AP; DeVore AD; Velazquez EJ

Eur J Heart Fail. 2019 08;21(8):1008-1011. Epub 2019-06-19.

PubMed abstract

Trimethylamine N-oxide and risk of heart failure progression: marker or mediator of disease

Authors: Chioncel O; Ambrosy AP

Eur J Heart Fail. 2019 08;21(8):1008-1011. Epub 2019-06-19.

PubMed abstract

Clinical Outcomes in Patients With Acute Decompensated Heart Failure Randomly Assigned to Sacubitril/Valsartan or Enalapril in the PIONEER-HF Trial

Authors: Morrow DA; Velazquez EJ; DeVore AD; Desai AS; Duffy CI; Ambrosy AP; Gurmu Y; McCague K; Rocha R; Braunwald E

Circulation. 2019 05 07;139(19):2285-2288.

PubMed abstract

Trends in Readmissions and Length of Stay for Patients Hospitalized With Heart Failure in Canada and the United States

Authors: Samsky MD; Ambrosy AP; Youngson E; Liang L; Kaul P; Hernandez AF; Peterson ED; McAlister FA

JAMA Cardiol. 2019 05 01;4(5):444-453.

PubMed abstract

Natriuretic peptides as a surrogate endpoint in clinical trials - a riddle wrapped in an enigma

Authors: Hardwick AB; Ambrosy AP

Eur J Heart Fail. 2019 05;21(5):621-623. Epub 2019-03-27.

PubMed abstract

Identifying responders to oral iron supplementation in heart failure with a reduced ejection fraction: a post-hoc analysis of the IRONOUT-HF trial

Authors: Ambrosy AP; Lewis GD; Malhotra R; Jones AD; Greene SJ; Fudim M; Coles A; Butler J; Sharma A; Hernandez AF; Mentz RJ

J Cataract Refract Surg. 2019 04;45(4):404-413. Epub 2019-01-09.

PubMed abstract

Applying data science approaches to identify frequent flyers in heart failure: rise of the machines

Authors: Ambrosy AP; Lee KK

Eur J Heart Fail. 2019 03;21(3):319-321. Epub 2019-02-07.

PubMed abstract

Burden of medical co-morbidities and benefit from surgical revascularization in patients with ischaemic cardiomyopathy

Authors: Ambrosy AP; STICH Trial Investigators; et al.

Eur J Heart Fail. 2019 03;21(3):373-381. Epub 2019-01-30.

PubMed abstract

Angiotensin-Neprilysin Inhibition in Acute Decompensated Heart Failure

Authors: Velazquez EJ; Morrow DA; DeVore AD; Duffy CI; Ambrosy AP; McCague K; Rocha R; Braunwald E; PIONEER-HF Investigators

N Engl J Med. 2019 02 07;380(6):539-548. Epub 2018-11-11.

PubMed abstract

Left Ventricular Global Longitudinal Strain Can Reliably Be Measured from a Single Apical Four-Chamber View in Patients with Heart Failure

Authors: Alenezi F; Ambrosy AP; Phelan M; Chiswell K; Abudaqa L; Alajmi H; Kisslo J; Velazquez EJ

J Am Soc Nephrol. 2019 09;30(9):1746-1755. Epub 2019-07-10.

PubMed abstract

Undiagnosed dysglycemia in patients hospitalized for worsening heart failure: not so sweet after all

Authors: Chioncel O; Ambrosy AP

Eur J Prev Cardiol. 2019 01;26(1):68-71. Epub 2018-10-28.

PubMed abstract

Is Time From Last Hospitalization for Heart Failure to Placement of a Primary Prevention Implantable Cardioverter-Defibrillator Associated With Patient Outcomes?

Authors: Ambrosy AP; Parzynski CS; Friedman DJ; Fudim M; Hernandez AF; Fonarow GC; Masoudi FA; Al-Khatib SM

Clin Chem. 2019 11;65(11):1448-1457. Epub 2019-10-02.

PubMed abstract

Relationship between timing of trial randomization, protocol completion, and clinical outcomes among patients hospitalized for heart failure: from the ASTRONAUT trial

Authors: Greene SJ; Ambrosy AP; Butler J; et al.

Eur J Heart Fail. 2018 12;20(12):1760-1763. Epub 2018-11-11.

PubMed abstract

Reassessing the Role of Surrogate End Points in Drug Development for Heart Failure

Authors: Greene SJ; Mentz RJ; Fiuzat M; Butler J; Solomon SD; Ambrosy AP; Mehta C; Teerlink JR; Zannad F; O'Connor CM

Circulation. 2018 09 04;138(10):1039-1053.

PubMed abstract

Improving Postdischarge Outcomes in Acute Heart Failure.

Authors: Chioncel, Ovidiu O; Collins, Sean P SP; Ambrosy, Andrew P AP; Pang, Peter S PS; Antohi, Elena-Laura EL; Iliescu, Vlad Anton VA; Maggioni, Aldo P AP; Butler, Javed J; Mebazaa, Alexandre A

American journal of therapeutics. 2018 Aug 17;25(4):e475-e486. Epub 2018-08-17.

PubMed abstract

Liraglutide and weight loss among patients with advanced heart failure and a reduced ejection fraction: insights from the FIGHT trial.

Authors: Sharma, Abhinav A; Ambrosy, Andrew P AP; DeVore, Adam D AD; Margulies, Kenneth B KB; McNulty, Steven E SE; Mentz, Robert J RJ; Hernandez, Adrian F AF; Michael Felker, Gary G; Cooper, Lauren B LB; Lala, Anuradha A; Vader, Justin J; Groake, John D JD; Borlaug, Barry A BA; Velazquez, Eric J EJ

ESC heart failure. 2018 Aug 17;122(9):1451-1458. Epub 2018-08-17.

PubMed abstract

Natural History of Patients Postacute Coronary Syndrome Based on Heart Failure Status.

Authors: Ambrosy, Andrew P AP; Cerbin, Lukasz P LP; Fudim, Marat M; Clare, Robert M RM; Lokhnygina, Yuliya Y; Braunwald, Eugene E; Califf, Robert M RM; Cannon, Christopher P CP; Tershakovec, Andrew M AM; Roe, Matthew T MT; Blazing, Michael A MA

The American journal of cardiology. 2018 Nov 01;122(9):1451-1458. Epub 2018-08-04.

PubMed abstract

Renal Function and Exercise Training in AmbulatoryHeart Failure Patients With a Reduced Ejection Fraction.

Authors: Ambrosy, Andrew P AP; Mulder, Hillary H; Coles, Adrian A; Krauss, William E WE; Lam, Carolyn S P CSP; McCullough, Peter A PA; Pina, Ileana I; Tromp, Jasper J; Whellan, David J DJ; O'Connor, Christopher M CM; Mentz, Robert J RJ

The American journal of cardiology. 2018 Sep 15;122(6):999-1007. Epub 2018-06-23.

PubMed abstract

Combination drug therapy in heart failure: greater than the sum of its parts.

Authors: Ambrosy, Andrew P AP; Chioncel, Ovidiu O

European journal of heart failure. 2018 Sep 17;20(9):1323-1325. Epub 2018-06-22.

PubMed abstract

Sudden Death After Hospitalization for Heart Failure With Reduced Ejection Fraction (from the EVEREST Trial).

Authors: Vaduganathan, Muthiah M; Patel, Ravi B RB; Mentz, Robert J RJ; Subacius, Haris H; Chatterjee, Neal A NA; Greene, Stephen J SJ; Ambrosy, Andrew P AP; Maggioni, Aldo P AP; Udelson, James E JE; Swedberg, Karl K; Konstam, Marvin A MA; O'Connor, Christopher M CM; Butler, Javed J; Gheorghiade, Mihai M; Zannad, Faiez F

The American journal of cardiology. 2018 Jul 15;122(2):255-260. Epub 2018-04-11.

PubMed abstract

Is Time of the Essence? The Impact of Time of Hospital Presentation in Acute Heart Failure: Insights From ASCEND-HF Trial.

Authors: Cerbin, Lukasz P LP; Ambrosy, Andrew P AP; Greene, Stephen J SJ; Armstrong, Paul W PW; Butler, Javed J; Coles, Adrian A; DeVore, Adam D AD; Ezekowitz, Justin A JA; Hernandez, Adrian F AF; Metra, Marco M; Starling, Randall C RC; Tang, Wilson W; Teerlink, John R JR; Voors, Adriaan A AA; Wu, Angie A; O'Connor, Christopher M CM; Mentz, Robert J RJ

JACC. Heart failure. 2018 Apr 15;6(4):298-307. Epub 2018-03-07.

PubMed abstract

The role of angiotensin receptor-neprilysin inhibitors in cardiovascular disease-existing evidence, knowledge gaps, and future directions.

Authors: Ambrosy, Andrew P AP; Mentz, Robert J RJ; Fiuzat, Mona M; Cleland, John G F JGF; Greene, Stephen J SJ; O'Connor, Christopher M CM; Teerlink, John R JR; Zannad, Faiez F; Solomon, Scott D SD

European journal of heart failure. 2018 Jun 15;20(6):963-972. Epub 2018-02-21.

PubMed abstract

Angiotensin receptor-neprilysin inhibitor therapy in heart failure: An end that justifies the means.

Authors: Ambrosy, Andrew P AP; Velazquez, Eric J EJ

American heart journal. 2018 May 17;199(9):176-177. Epub 2018-02-15.

PubMed abstract

Predictors of Post-discharge Mortality Among Patients Hospitalized for Acute Heart Failure.

Authors: Chioncel, Ovidiu O; Collins, Sean P SP; Greene, Stephen J SJ; Pang, Peter S PS; Ambrosy, Andrew P AP; Antohi, Elena-Laura EL; Vaduganathan, Muthiah M; Butler, Javed J; Gheorghiade, Mihai M

Cardiac failure review. 2017 Nov 03;3(2):122-129. Epub 2018-02-03.

PubMed abstract

Expanded algorithm for managing patients with acute decompensated heart failure.

Authors: Njoroge, Joyce N JN; Cheema, Baljash B; Ambrosy, Andrew P AP; Greene, Stephen J SJ; Collins, Sean P SP; Vaduganathan, Muthiah M; Mebazaa, Alexandre A; Chioncel, Ovidiu O; Butler, Javed J; Gheorghiade, Mihai M

Heart failure reviews. 2018 Jul 15;23(4):597-607. Epub 2018-01-10.

PubMed abstract

Rationale and design of the comParIson Of sacubitril/valsartaN versus Enalapril on Effect on nt-pRo-bnp in patients stabilized from an acute Heart Failure episode (PIONEER-HF) trial.

Authors: Velazquez, Eric J EJ; Morrow, David A DA; DeVore, Adam D AD; Ambrosy, Andrew P AP; Duffy, Carol I CI; McCague, Kevin K; Hernandez, Adrian F AF; Rocha, Ricardo A RA; Braunwald, Eugene E

American heart journal. 2018 Apr 15;198(2):145-151. Epub 2018-01-10.

PubMed abstract

Sudden cardiac death following admission for acute heart failure: adding insult to injury.

Authors: Ambrosy, Andrew P AP; Fudim, Marat M; Chioncel, Ovidiu O

European journal of heart failure. 2018 03 03;20(3):533-535. Epub 2018-01-04.

PubMed abstract

Aetiology, timing and clinical predictors of early vs. late readmission following index hospitalization for acute heart failure: insights from ASCEND-HF.

Authors: Fudim, Marat M; O'Connor, Christopher M CM; Dunning, Allison A; Ambrosy, Andrew P AP; Armstrong, Paul W PW; Coles, Adrian A; Ezekowitz, Justin A JA; Greene, Stephen J SJ; Metra, Marco M; Starling, Randall C RC; Voors, Adriaan A AA; Hernandez, Adrian F AF; Michael Felker, G G; Mentz, Robert J RJ

European journal of heart failure. 2018 02 03;20(2):304-314. Epub 2017-10-29.

PubMed abstract

Lessons learned in acute heart failure.

Authors: Cheema, Baljash B; Ambrosy, Andrew P AP; Kaplan, Rachel M RM; Senni, Michele M; Fonarow, Gregg C GC; Chioncel, Ovidiu O; Butler, Javed J; Gheorghiade, Mihai M

European journal of heart failure. 2018 04 03;20(4):630-641. Epub 2017-10-29.

PubMed abstract

Pre-discharge and early post-discharge troponin elevation among patients hospitalized for heart failure with reduced ejection fraction: findings from the ASTRONAUT trial.

Authors: Greene, Stephen J SJ; Butler, Javed J; Fonarow, Gregg C GC; Subacius, Haris P HP; Ambrosy, Andrew P AP; Vaduganathan, Muthiah M; Triggiani, Marco M; Solomon, Scott D SD; Lewis, Eldrin F EF; Maggioni, Aldo P AP; Böhm, Michael M; Chioncel, Ovidiu O; Nodari, Savina S; Senni, Michele M; Zannad, Faiez F; Gheorghiade, Mihai M;

European journal of heart failure. 2018 02 03;20(2):281-291. Epub 2017-10-17.

PubMed abstract

Real-world dosing of evidence-based medications for heart failure: embracing guideline recommendations and clinical judgement.

Authors: Ambrosy, Andrew P AP; Gheorghiade, Mihai M

European journal of heart failure. 2017 11 03;19(11):1424-1426. Epub 2017-08-08.

PubMed abstract

Clinical profiles in acute heart failure: one size fits all or not at all?

Authors: Ambrosy, Andrew P AP; Gheorghiade, Mihai M

European journal of heart failure. 2017 10 03;19(10):1255-1257. Epub 2017-08-08.

PubMed abstract

Building the case for aerobic exercise in ambulatory patients with heart failure and a reduced ejection fraction.

Authors: Cerbin, Lukasz P LP; Ambrosy, Andrew P AP; Mentz, Robert J RJ

American heart journal. 2017 Oct 03;192(2):e3. Epub 2017-07-15.

PubMed abstract

Hospitalization for Recently Diagnosed Versus Worsening Chronic Heart Failure: From the ASCEND-HF Trial.

Authors: Greene, Stephen J SJ; Hernandez, Adrian F AF; Dunning, Allison A; Ambrosy, Andrew P AP; Armstrong, Paul W PW; Butler, Javed J; Cerbin, Lukasz P LP; Coles, Adrian A; Ezekowitz, Justin A JA; Metra, Marco M; Starling, Randall C RC; Teerlink, John R JR; Voors, Adriaan A AA; O'Connor, Christopher M CM; Mentz, Robert J RJ

Journal of the American College of Cardiology. 2017 Jun 27;69(25):3029-3039. Epub 2017-06-28.

PubMed abstract

Clinical trials in acute heart failure: beginning of the end or end of the beginning?

Authors: Ambrosy, Andrew P AP; Butler, Javed J; Gheorghiade, Mihai M

European journal of heart failure. 2017 11 03;19(11):1358-1360. Epub 2017-06-28.

PubMed abstract

Body Weight Change During and After Hospitalization for Acute Heart Failure: Patient Characteristics, Markers of Congestion, and Outcomes: Findings From the ASCEND-HF Trial.

Authors: Ambrosy, Andrew P AP; Cerbin, Lukasz P LP; Armstrong, Paul W PW; Butler, Javed J; Coles, Adrian A; DeVore, Adam D AD; Dunlap, Mark E ME; Ezekowitz, Justin A JA; Felker, G Michael GM; Fudim, Marat M; Greene, Stephen J SJ; Hernandez, Adrian F AF; O'Connor, Christopher M CM; Schulte, Philip P; Starling, Randall C RC; Teerlink, John R JR; Voors, Adriaan A AA; Mentz, Robert J RJ

JACC. Heart failure. 2017 01 01;5(1):1-13. Epub 2017-01-19.

PubMed abstract

Global Variations in Patient Populations and Outcomes in Heart Failure Clinical Trials.

Authors: Egwim, Chidiebube C; Dixon, Brittany B; Ambrosy, Andrew P AP; Mentz, Robert J RJ

Current heart failure reports. 2017 02 01;14(1):30-39. Epub 2017-01-19.

PubMed abstract

Reply: Factors That May Affect Body Change During and After Hospitalization for Acute Heart Failure.

Authors: Cerbin, Lukasz P LP; Ambrosy, Andrew P AP; Mentz, Robert J RJ

JACC. Heart failure. 2017 04 01;5(4):311-312. Epub 2017-01-19.

PubMed abstract

Aerobic exercise training and general health status in ambulatory heart failure patients with a reduced ejection fraction-Findings from the Heart Failure and A Controlled Trial Investigating Outcomes of Exercise Training (HF-ACTION)trial.

Authors: Ambrosy, Andrew P AP; Cerbin, Lukasz P LP; DeVore, Adam D AD; Greene, Stephen J SJ; Kraus, William E WE; O'Connor, Christopher M CM; Piña, Ileana L IL; Whellan, David J DJ; Wojdyla, Daniel D; Wu, Angie A; Mentz, Robert J RJ

American heart journal. 2017 Apr 01;186(1):130-138. Epub 2017-01-19.

PubMed abstract

Natriuretic peptide-guided management in heart failure.

Authors: Chioncel, Ovidiu O; Collins, Sean P SP; Greene, Stephen J SJ; Ambrosy, Andrew P AP; Vaduganathan, Muthiah M; Macarie, Cezar C; Butler, Javed J; Gheorghiade, Mihai M

Journal of cardiovascular medicine (Hagerstown, Md.). 2016 Aug 01;17(8):556-68. Epub 2016-10-17.

PubMed abstract

Digoxin for Worsening Chronic Heart Failure: Underutilized and Underrated.

Authors: Ambrosy, Andrew P AP; Pang, Peter S PS; Gheorghiade, Mihai M

JACC. Heart failure. 2016 05 01;4(5):365-7. Epub 2016-10-17.

PubMed abstract

Changes in Dyspnea Status During Hospitalization and Postdischarge Health-Related Quality of Life in Patients Hospitalized for Heart Failure: Findings From the EVEREST Trial.

Authors: Ambrosy, Andrew P AP; Khan, Hassan H; Udelson, James E JE; Mentz, Robert J RJ; Chioncel, Ovidiu O; Greene, Stephen J SJ; Vaduganathan, Muthiah M; Subacuis, Haris P HP; Konstam, Marvin A MA; Swedberg, Karl K; Zannad, Faiez F; Maggioni, Aldo P AP; Gheorghiade, Mihai M; Butler, Javed J

Circulation. Heart failure. 2016 05 01;9(5):419-27. Epub 2016-10-17.

PubMed abstract

Heart Failure Clinical Trials in East and Southeast Asia: Understanding the Importance and Defining the Next Steps.

Authors: Mentz, Robert J RJ; Roessig, Lothar L; Greenberg, Barry H BH; Sato, Naoki N; Shinagawa, Kaori K; Yeo, Daniel D; Kwok, Bernard W K BW; Reyes, Eugenio B EB; Krum, Henry H; Pieske, Burkert B; Greene, Stephen J SJ; Ambrosy, Andrew P AP; Kelly, Jacob P JP; Zannad, Faiez F; Pitt, Bertram B; Lam, Carolyn S P CS

JACC. Heart failure. 2016 06 01;4(6):419-27. Epub 2016-10-17.

PubMed abstract

Influence of Clinical Trial Site Enrollment on Patient Characteristics, Protocol Completion, and End Points: Insights From the ASCEND-HF Trial (Acute Study of Clinical Effectiveness of Nesiritide in Decompensated Heart Failure).

Authors: Greene, Stephen J SJ; Hernandez, Adrian F AF; Sun, Jie-Lena JL; Metra, Marco M; Butler, Javed J; Ambrosy, Andrew P AP; Ezekowitz, Justin A JA; Starling, Randall C RC; Teerlink, John R JR; Schulte, Phillip J PJ; Voors, Adriaan A AA; Armstrong, Paul W PW; O'Connor, Christopher M CM; Mentz, Robert J RJ

Circulation. Heart failure. 2016 09 01;9(9):552-562. Epub 2016-10-17.

PubMed abstract

Targeting digoxin dosing to serum concentration: is the bullseye too small?

Authors: Ambrosy, Andrew P AP; Gheorghiade, Mihai M

European journal of heart failure. 2016 08 01;18(8):1082-4. Epub 2016-10-17.

PubMed abstract

Influence of atrial fibrillation on post-discharge natriuretic peptide trajectory and clinical outcomes among patients hospitalized for heart failure: insights from the ASTRONAUT trial.

Authors: Greene, Stephen J SJ; Fonarow, Gregg C GC; Solomon, Scott D SD; Subacius, Haris P HP; Ambrosy, Andrew P AP; Vaduganathan, Muthiah M; Maggioni, Aldo P AP; Böhm, Michael M; Lewis, Eldrin F EF; Zannad, Faiez F; Butler, Javed J; Gheorghiade, Mihai M;

European journal of heart failure. 2017 04 01;19(4):552-562. Epub 2016-10-17.

PubMed abstract

In-Hospital Diuretic Agent Use and Post-Discharge Clinical Outcomes in Patients Hospitalized for Worsening Heart Failure: Insights From the EVEREST Trial.

Authors: Mecklai, Alicia A; Subačius, Haris H; Konstam, Marvin A MA; Gheorghiade, Mihai M; Butler, Javed J; Ambrosy, Andrew P AP; Katz, Stuart D SD

JACC. Heart failure. 2016 07 01;4(7):580-588. Epub 2016-03-30.

PubMed abstract

Serum Osmolality and Postdischarge Outcomes After Hospitalization for Heart Failure.

Authors: Vaduganathan, Muthiah M; Marti, Catherine N CN; Mentz, Robert J RJ; Greene, Stephen J SJ; Ambrosy, Andrew P AP; Subacius, Haris P HP; Fonarow, Gregg C GC; Chioncel, Ovidiu O; Bazari, Hasan H; Maggioni, Aldo P AP; Zannad, Faiez F; Konstam, Marvin A MA; Sato, Naoki N; Gheorghiade, Mihai M; Butler, Javed J;

The American journal of cardiology. 2016 Apr 01;117(7):1144-50. Epub 2016-01-14.

PubMed abstract

The clinical course of health status and association with outcomes in patients hospitalized for heart failure: insights from ASCEND-HF.

Authors: Ambrosy, Andrew P AP; Hernandez, Adrian F AF; Armstrong, Paul W PW; Butler, Javed J; Dunning, Allison A; Ezekowitz, Justin A JA; Felker, G Michael GM; Greene, Stephen J SJ; Kaul, Padma P; McMurray, John J JJ; Metra, Marco M; O'Connor, Christopher M CM; Reed, Shelby D SD; Schulte, Phillip J PJ; Starling, Randall C RC; Tang, W H Wilson WH; Voors, Adriaan A AA; Mentz, Robert J RJ

European journal of heart failure. 2016 Mar 01;18(3):306-13. Epub 2015-10-14.

PubMed abstract

Identifying Barriers and Practical Solutions to Conducting Site-Based Research in North America: Exploring Acute Heart Failure Trials As a Case Study.

Authors: Ambrosy, Andrew P AP; Mentz, Robert J RJ; Krishnamoorthy, Arun A; Greene, Stephen J SJ; Severance, Harry W HW

Heart failure clinics. 2015 Oct 01;11(4):581-9. Epub 2015-08-04.

PubMed abstract

Hospitalized Heart Failure in the United States: Lessons Learned from Clinical Trial Populations.

Authors: Greene, Stephen J SJ; AlKhawam, Lora L; Ambrosy, Andrew P AP; Vaduganathan, Muthiah M; Mentz, Robert J RJ

Heart failure clinics. 2015 Oct 01;11(4):591-601. Epub 2015-08-04.

PubMed abstract

Pulmonary Oedema-Therapeutic Targets.

Authors: Chioncel, Ovidiu O; Collins, Sean P SP; Ambrosy, Andrew P AP; Gheorghiade, Mihai M; Filippatos, Gerasimos G

Cardiac failure review. 2015 Apr 01;1(1):38-45. Epub 2015-05-09.

PubMed abstract

Length of hospital stay and 30-day readmission following heart failure hospitalization: insights from the EVEREST trial.

Authors: Khan, Hassan H; Greene, Stephen J SJ; Fonarow, Gregg C GC; Kalogeropoulos, Andreas P AP; Ambrosy, Andrew P AP; Maggioni, Aldo P AP; Zannad, Faiez F; Konstam, Marvin A MA; Swedberg, Karl K; Yancy, Clyde W CW; Gheorghiade, Mihai M; Butler, Javed J;

European journal of heart failure. 2015 Oct 01;17(10):1022-31. Epub 2015-05-09.

PubMed abstract

International REgistry to assess medical Practice with lOngitudinal obseRvation for Treatment of Heart Failure (REPORT-HF): rationale for and design of a global registry.

Authors: Filippatos, Gerasimos G; Khan, Sadiya Sana SS; Ambrosy, Andrew P AP; Cleland, John G F JG; Collins, Sean P SP; Lam, Carolyn S P CS; Angermann, Christiane E CE; Ertl, Georg G; Dahlström, Ulf U; Hu, Dayi D; Dickstein, Kenneth K; Perrone, Sergio V SV; Ghadanfar, Mathieu M; Bermann, Georgina G; Noe, Adele A; Schweizer, Anja A; Maier, Thomas T; Gheorghiade, Mihai M

European journal of heart failure. 2015 May 01;17(5):527-33. Epub 2015-03-10.

PubMed abstract

Effect of minor liver function test abnormalities and values within the normal range on survival in heart failure.

Authors: Ambrosy, Andrew P AP; Dunn, Timothy P TP; Heidenreich, Paul A PA

The American journal of cardiology. 2015 Apr 01;115(7):938-41. Epub 2015-01-28.

PubMed abstract

Epidemiology, pathophysiology, and in-hospital management of pulmonary edema: data from the Romanian Acute Heart Failure Syndromes registry.

Authors: Chioncel, Ovidiu O; Ambrosy, Andrew P AP; Bubenek, Serban S; Filipescu, Daniela D; Vinereanu, Dragos D; Petris, Antoniu A; Christodorescu, Ruxandra R; Macarie, Cezar C; Gheorghiade, Mihai M; Collins, Sean P SP;

Journal of cardiovascular medicine (Hagerstown, Md.). 2016 Feb 01;17(2):92-104. Epub 2014-09-16.

PubMed abstract

Global perspectives in hospitalized heart failure: regional and ethnic variation in patient characteristics, management, and outcomes.

Authors: Ambrosy, Andrew P AP; Gheorghiade, Mihai M; Chioncel, Ovidiu O; Mentz, Robert J RJ; Butler, Javed J

Current heart failure reports. 2014 Dec 01;11(4):416-27. Epub 2014-09-16.

PubMed abstract

Relation of serum uric acid levels and outcomes among patients hospitalized for worsening heart failure with reduced ejection fraction (from the efficacy of vasopressin antagonism in heart failure outcome study with tolvaptan trial).

Authors: Vaduganathan, Muthiah M; Greene, Stephen J SJ; Ambrosy, Andrew P AP; Mentz, Robert J RJ; Subacius, Haris P HP; Chioncel, Ovidiu O; Maggioni, Aldo P AP; Swedberg, Karl K; Zannad, Faiez F; Konstam, Marvin A MA; Senni, Michele M; Givertz, Michael M MM; Butler, Javed J; Gheorghiade, Mihai M;

The American journal of cardiology. 2014 Dec 01;114(11):1713-21. Epub 2014-09-16.

PubMed abstract

Designing effective drug and device development programs for hospitalized heart failure: a proposal for pretrial registries.

Authors: Greene, Stephen J SJ; Shah, Ami N AN; Butler, Javed J; Ambrosy, Andrew P AP; Anker, Stefan D SD; Chioncel, Ovidiu O; Collins, Sean P SP; Dinh, Wilfried W; Dunnmon, Preston M PM; Fonarow, Gregg C GC; Lam, Carolyn S P CS; Mentz, Robert J RJ; Pieske, Burkert B; Roessig, Lothar L; Rosano, Giuseppe M C GM; Sato, Naoki N; Vaduganathan, Muthiah M; Gheorghiade, Mihai M

American heart journal. 2014 Aug 01;168(2):142-9. Epub 2014-05-24.

PubMed abstract

Patterns of intensive care unit admissions in patients hospitalized for heart failure: insights from the RO-AHFS registry.

Authors: Chioncel, Ovidiu O; Ambrosy, Andrew P AP; Filipescu, Daniela D; Bubenek, Serban S; Vinereanu, Dragos D; Petris, Antoniu A; Collins, Sean P SP; Macarie, Cezar C; Gheorghiade, Mihai M;

Journal of cardiovascular medicine (Hagerstown, Md.). 2015 May 01;16(5):331-40. Epub 2014-04-15.

PubMed abstract

Clinical profile and prognostic value of anemia at the time of admission and discharge among patients hospitalized for heart failure with reduced ejection fraction: findings from the EVEREST trial.

Authors: Mentz, Robert J RJ; Greene, Stephen J SJ; Ambrosy, Andrew P AP; Vaduganathan, Muthiah M; Subacius, Haris P HP; Swedberg, Karl K; Maggioni, Aldo P AP; Nodari, Savina S; Ponikowski, Piotr P; Anker, Stefan D SD; Butler, Javed J; Gheorghiade, Mihai M

Circulation. Heart failure. 2014 May 01;7(3):401-8. Epub 2014-04-15.

PubMed abstract

Lipids, statins, and clinical outcomes in heart failure: rethinking the data.

Authors: Vaduganathan, Muthiah M; Greene, Stephen J SJ; Ambrosy, Andrew P AP; Gheorghiade, Mihai M

Heart failure reviews. 2014 Nov 13;19(6):695-8. Epub 2014-03-05.

PubMed abstract

The use of digoxin in patients with worsening chronic heart failure: reconsidering an old drug to reduce hospital admissions.

Authors: Ambrosy, Andrew P AP; Butler, Javed J; Ahmed, Ali A; Vaduganathan, Muthiah M; van Veldhuisen, Dirk J DJ; Colucci, Wilson S WS; Gheorghiade, Mihai M

Journal of the American College of Cardiology. 2014 May 13;63(18):1823-32. Epub 2014-03-05.

PubMed abstract

The predictive value of transaminases at admission in patients hospitalized for heart failure: findings from the RO-AHFS registry.

Authors: Ambrosy, Andrew P AP; Gheorghiade, Mihai M; Bubenek, Serban S; Vinereanu, Dragos D; Vaduganathan, Muthiah M; Macarie, Cezar C; Chioncel, Ovidiu O;

European heart journal. Acute cardiovascular care. 2013 Jun 01;2(2):99-108. Epub 2014-02-05.

PubMed abstract

The global health and economic burden of hospitalizations for heart failure: lessons learned from hospitalized heart failure registries.

Authors: Ambrosy, Andrew P AP; Fonarow, Gregg C GC; Butler, Javed J; Chioncel, Ovidiu O; Greene, Stephen J SJ; Vaduganathan, Muthiah M; Nodari, Savina S; Lam, Carolyn S P CSP; Sato, Naoki N; Shah, Ami N AN; Gheorghiade, Mihai M

Journal of the American College of Cardiology. 2014 Apr 01;63(12):1123-1133. Epub 2014-02-05.

PubMed abstract

Relation of serum magnesium levels and postdischarge outcomes in patients hospitalized for heart failure (from the EVEREST Trial).

Authors: Vaduganathan, Muthiah M; Greene, Stephen J SJ; Ambrosy, Andrew P AP; Mentz, Robert J RJ; Fonarow, Gregg C GC; Zannad, Faiez F; Maggioni, Aldo P AP; Konstam, Marvin A MA; Subacius, Haris P HP; Nodari, Savina S; Butler, Javed J; Gheorghiade, Mihai M;

The American journal of cardiology. 2013 Dec 01;112(11):1763-9. Epub 2013-10-04.

PubMed abstract

Haemoconcentration, renal function, and post-discharge outcomes among patients hospitalized for heart failure with reduced ejection fraction: insights from the EVEREST trial.

Authors: Greene, Stephen J SJ; Gheorghiade, Mihai M; Vaduganathan, Muthiah M; Ambrosy, Andrew P AP; Mentz, Robert J RJ; Subacius, Haris H; Maggioni, Aldo P AP; Nodari, Savina S; Konstam, Marvin A MA; Butler, Javed J; Filippatos, Gerasimos G;

European journal of heart failure. 2013 Dec 01;15(12):1401-11. Epub 2013-07-11.

PubMed abstract

Not time to RELAX in acute heart failure.

Authors: Ambrosy, Andrew P AP; Witteles, Ronald M RM

Lancet (London, England). 2013 May 25;381(9880):1813. Epub 2013-07-11.

PubMed abstract

Hepatic abscess with biliary communication following transarterial chemoembolization of hepatocellular carcinoma.

Authors: Huang, Robert J RJ; Ambrosy, Andrew P AP; Triadafilopoulos, George G

Digestive diseases and sciences. 2013 Sep 25;58(9):2463-5. Epub 2013-02-20.

PubMed abstract

The disconnect between phase II and phase III trials of drugs for heart failure.

Authors: Vaduganathan, Muthiah M; Greene, Stephen J SJ; Ambrosy, Andrew P AP; Gheorghiade, Mihai M; Butler, Javed J

Nature reviews. Cardiology. 2013 Feb 25;10(2):85-97. Epub 2013-01-08.

PubMed abstract

Clinical course and predictive value of congestion during hospitalization in patients admitted for worsening signs and symptoms of heart failure with reduced ejection fraction: findings from the EVEREST trial.

Authors: Ambrosy, Andrew P AP; Pang, Peter S PS; Khan, Sadiya S; Konstam, Marvin A MA; Fonarow, Gregg C GC; Traver, Brian B; Maggioni, Aldo P AP; Cook, Thomas T; Swedberg, Karl K; Burnett, John C JC; Grinfeld, Liliana L; Udelson, James E JE; Zannad, Faiez F; Gheorghiade, Mihai M;

European heart journal. 2013 Mar 25;34(11):835-43. Epub 2013-01-04.

PubMed abstract

Clinical profile and prognostic value of low systolic blood pressure in patients hospitalized for heart failure with reduced ejection fraction: insights from the Efficacy of Vasopressin Antagonism in Heart Failure: Outcome Study with Tolvaptan (EVEREST) trial.

Authors: Ambrosy, Andrew P AP; Vaduganathan, Muthiah M; Mentz, Robert J RJ; Greene, Stephen J SJ; Subačius, Haris H; Konstam, Marvin A MA; Maggioni, Aldo P AP; Swedberg, Karl K; Gheorghiade, Mihai M

American heart journal. 2013 Feb 25;165(2):216-25. Epub 2012-12-29.

PubMed abstract

Association of arginine vasopressin levels with outcomes and the effect of V2 blockade in patients hospitalized for heart failure with reduced ejection fraction: insights from the EVEREST trial.

Authors: Lanfear, David E DE; Sabbah, Hani N HN; Goldsmith, Steven R SR; Greene, Stephen J SJ; Ambrosy, Andrew P AP; Fought, Angela J AJ; Kwasny, Mary J MJ; Swedberg, Karl K; Yancy, Clyde W CW; Konstam, Marvin A MA; Maggioni, Aldo P AP; Zannad, Faiez F; Gheorghiade, Mihai M;

Circulation. Heart failure. 2013 Jan 05;6(1):47-52. Epub 2012-12-12.

PubMed abstract

Relationship between clinical trial site enrollment with participant characteristics, protocol completion, and outcomes: insights from the EVEREST (Efficacy of Vasopressin Antagonism in Heart Failure: Outcome Study with Tolvaptan) trial.

Authors: Butler, Javed J; Subacius, Haris H; Vaduganathan, Muthiah M; Fonarow, Gregg C GC; Ambrosy, Andrew P AP; Konstam, Marvin A MA; Maggioni, Aldo A; Mentz, Robert J RJ; Swedberg, Karl K; Zannad, Faiez F; Gheorghiade, Mihai M;

Journal of the American College of Cardiology. 2013 Feb 05;61(5):571-9. Epub 2012-12-12.

PubMed abstract

Prognostic significance of serum total cholesterol and triglyceride levels in patients hospitalized for heart failure with reduced ejection fraction (from the EVEREST Trial).

Authors: Greene, Stephen J SJ; Vaduganathan, Muthiah M; Lupi, Laura L; Ambrosy, Andrew P AP; Mentz, Robert J RJ; Konstam, Marvin A MA; Nodari, Savina S; Subacius, Haris P HP; Fonarow, Gregg C GC; Bonow, Robert O RO; Gheorghiade, Mihai M;

The American journal of cardiology. 2013 Feb 15;111(4):574-81. Epub 2012-12-01.

PubMed abstract

Atrial fibrillation or flutter on initial electrocardiogram is associated with worse outcomes in patients admitted for worsening heart failure with reduced ejection fraction: findings from the EVEREST Trial.

Authors: Mentz, Robert J RJ; Chung, Matthew J MJ; Gheorghiade, Mihai M; Pang, Peter S PS; Kwasny, Mary J MJ; Ambrosy, Andrew P AP; Vaduganathan, Muthiah M; O'Connor, Christopher M CM; Swedberg, Karl K; Zannad, Faiez F; Konstam, Marvin A MA; Maggioni, Aldo P AP

American heart journal. 2012 Dec 15;164(6):884-92.e2. Epub 2012-10-29.

PubMed abstract

Predictive value of low relative lymphocyte count in patients hospitalized for heart failure with reduced ejection fraction: insights from the EVEREST trial.

Authors: Vaduganathan, Muthiah M; Ambrosy, Andrew P AP; Greene, Stephen J SJ; Mentz, Robert J RJ; Subacius, Haris P HP; Maggioni, Aldo P AP; Swedberg, Karl K; Nodari, Savina S; Zannad, Faiez F; Konstam, Marvin A MA; Butler, Javed J; Gheorghiade, Mihai M;

Circulation. Heart failure. 2012 Nov 15;5(6):750-8. Epub 2012-10-09.

PubMed abstract

Influence of documented history of coronary artery disease on outcomes in patients admitted for worsening heart failure with reduced ejection fraction in the EVEREST trial.

Authors: Mentz, Robert J RJ; Allen, Bradley D BD; Kwasny, Mary J MJ; Konstam, Marvin A MA; Udelson, James E JE; Ambrosy, Andrew P AP; Fought, Angela J AJ; Vaduganathan, Muthiah M; O'Connor, Christopher M CM; Zannad, Faiez F; Maggioni, Aldo P AP; Swedberg, Karl K; Bonow, Robert O RO; Gheorghiade, Mihai M

European journal of heart failure. 2013 Jan 15;15(1):61-8. Epub 2012-09-11.

PubMed abstract

Capecitabine-induced chest pain relieved by diltiazem.

Authors: Ambrosy, Andrew P AP; Kunz, Pamela L PL; Fisher, George A GA; Witteles, Ronald M RM

The American journal of cardiology. 2012 Dec 01;110(11):1623-6. Epub 2012-08-31.

PubMed abstract

Combining SERCA2a activation and Na-K ATPase inhibition: a promising new approach to managing acute heart failure syndromes with low cardiac output.

Authors: Gheorghiade, Mihai M; Ambrosy, Andrew P AP; Ferrandi, Mara M; Ferrari, Patrizia P

Discovery medicine. 2011 Aug 01;12(63):141-51. Epub 2012-06-04.

PubMed abstract

A comprehensive, longitudinal description of the in-hospital and post-discharge clinical, laboratory, and neurohormonal course of patients with heart failure who die or are re-hospitalized within 90 days: analysis from the EVEREST trial.

Authors: Gheorghiade, Mihai M; Pang, Peter S PS; Ambrosy, Andrew P AP; Lan, Gloria G; Schmidt, Philip P; Filippatos, Gerasimos G; Konstam, Marvin M; Swedberg, Karl K; Cook, Thomas T; Traver, Brian B; Maggioni, Aldo A; Burnett, John J; Grinfeld, Liliana L; Udelson, James J; Zannad, Faiez F

Heart failure reviews. 2012 May 01;17(3):485-509. Epub 2012-06-04.

PubMed abstract

Clinical course and predictive value of liver function tests in patients hospitalized for worsening heart failure with reduced ejection fraction: an analysis of the EVEREST trial.

Authors: Ambrosy, Andrew P AP; Vaduganathan, Muthiah M; Huffman, Mark D MD; Khan, Sadiya S; Kwasny, Mary J MJ; Fought, Angela J AJ; Maggioni, Aldo P AP; Swedberg, Karl K; Konstam, Marvin A MA; Zannad, Faiez F; Gheorghiade, Mihai M;

European journal of heart failure. 2012 Mar 01;14(3):302-11. Epub 2012-06-04.

PubMed abstract

B-type natriuretic peptide assessment in ambulatory heart failure patients: insights from IMPROVE HF.

Authors: Ambrosy, Andrew P AP; Fonarow, Gregg C GC; Albert, Nancy M NM; Curtis, Anne B AB; Heywood, J Thomas JT; Mehra, Mandeep R MR; O'Connor, Christopher M CM; Reynolds, Dwight D; Walsh, Mary N MN; Yancy, Clyde W CW; Gheorghiade, Mihai M

Journal of cardiovascular medicine (Hagerstown, Md.). 2012 Jun 01;13(6):360-7. Epub 2012-06-04.

PubMed abstract

Current management and future directions for the treatment of patients hospitalized for heart failure with low blood pressure.

Authors: Gheorghiade, Mihai M; Vaduganathan, Muthiah M; Ambrosy, Andrew A; Böhm, Michael M; Campia, Umberto U; Cleland, John G F JG; Fedele, Francesco F; Fonarow, Gregg C GC; Maggioni, Aldo P AP; Mebazaa, Alexandre A; Mehra, Mandeep M; Metra, Marco M; Nodari, Savina S; Pang, Peter S PS; Ponikowski, Piotr P; Sabbah, Hani N HN; Komajda, Michel M; Butler, Javed J

Heart failure reviews. 2013 Mar 01;18(2):107-22. Epub 2012-06-04.

PubMed abstract

The impact of chronic obstructive pulmonary disease in patients hospitalized for worsening heart failure with reduced ejection fraction: an analysis of the EVEREST Trial.

Authors: Mentz, Robert J RJ; Schmidt, Philip H PH; Kwasny, Mary J MJ; Ambrosy, Andrew P AP; O'Connor, Christopher M CM; Konstam, Marvin A MA; Zannad, Faiez F; Maggioni, Aldo P AP; Swedberg, Karl K; Gheorghiade, Mihai M

Journal of cardiac failure. 2012 Jul 01;18(7):515-23. Epub 2012-06-04.

PubMed abstract

Changes in renal function during hospitalization and soon after discharge in patients admitted for worsening heart failure in the placebo group of the EVEREST trial.

Authors: Blair, John E A JE; Pang, Peter S PS; Schrier, Robert W RW; Metra, Marco M; Traver, Brian B; Cook, Thomas T; Campia, Umberto U; Ambrosy, Andrew A; Burnett, John C JC; Grinfeld, Liliana L; Maggioni, Aldo P AP; Swedberg, Karl K; Udelson, James E JE; Zannad, Faiez F; Konstam, Marvin A MA; Gheorghiade, Mihai M;

European heart journal. 2011 Oct 01;32(20):2563-72. Epub 2011-07-23.

PubMed abstract

Coronary multidetector computed tomographic angiography to evaluate coronary artery disease in liver transplant candidates: methods, feasibility and initial experience.

Authors: Keeling, Aoife N AN; Flaherty, James D JD; Davarpanah, Amir H AH; Ambrosy, Andrew A; Farrelly, Cormac T CT; Harinstein, Matthew E ME; Flamm, Steven L SL; Abecassis, Michael I MI; Skaro, Anton I AI; Carr, James C JC; Gheorghiade, Mihai M

Journal of cardiovascular medicine (Hagerstown, Md.). 2011 Jul 01;12(7):460-8. Epub 2011-06-15.

PubMed abstract

The Romanian Acute Heart Failure Syndromes (RO-AHFS) registry.

Authors: Chioncel, Ovidiu O; Vinereanu, Dragos D; Datcu, Mihai M; Ionescu, Dan Dominic DD; Capalneanu, Radu R; Brukner, Ioan I; Dorobantu, Maria M; Ambrosy, Andrew A; Macarie, Cezar C; Gheorghiade, Mihai M

American heart journal. 2011 Jul 01;162(1):142-53.e1. Epub 2011-06-15.

PubMed abstract

Eplerenone reduces risk of cardiovascular death or hospitalisation in heart failure patients with reduced ejection fraction.

Authors: Ambrosy, Andrew A; Gheorghiade, Mihai M

Evidence-based medicine. 2011 Aug 01;16(4):121-2. Epub 2011-05-10.

PubMed abstract

Heart failure in 2010: one step forward, two steps back.

Authors: Gheorghiade, Mihai M; Ambrosy, Andrew A

Nature reviews. Cardiology. 2011 Feb 01;8(2):72-3. Epub 2011-03-15.

PubMed abstract

Acute heart failure syndromes: assessment and reconstructing the heart.

Authors: Ambrosy, Andrew A; Wilcox, Jane J; Nodari, Savina S; Gheorghiade, Mihai M

Journal of cardiovascular medicine (Hagerstown, Md.). 2011 Apr 01;12(4):258-63. Epub 2011-03-15.

PubMed abstract

Tolvaptan for the treatment of heart failure: a review of the literature.

Authors: Ambrosy, Andrew A; Goldsmith, Steven R SR; Gheorghiade, Mihai M

Expert opinion on pharmacotherapy. 2011 Apr 01;12(6):961-76. Epub 2011-03-15.

PubMed abstract

Recurrent headaches in children: an epidemiological survey of two middle schools in inner city Chicago.

Authors: Nyame, Yaw A YA; Ambrosy, Andrew P AP; Saps, Miguel M; Adams, Papa N PN; Dhroove, Gati N GN; Suresh, Santhanam S

Pain practice : the official journal of World Institute of Pain. 2011 Feb 01;10(3):214-21. Epub 2010-01-08.

PubMed abstract

Parent-assisted or nurse-assisted epidural analgesia: is this feasible in pediatric patients?

Authors: Birmingham, Patrick K PK; Suresh, Santhanam S; Ambrosy, Andrew A; Porfyris, Suzanne S

Paediatric anaesthesia. 2009 Nov 01;19(11):1084-9. Epub 2010-01-08.

PubMed abstract

Unilateral groin surgery in children: will the addition of an ultrasound-guided ilioinguinal nerve block enhance the duration of analgesia of a single-shot caudal block?

Authors: Jagannathan, Narasimhan N; Sohn, Lisa L; Sawardekar, Amod A; Ambrosy, Andrew A; Hagerty, Jennifer J; Chin, Anthony A; Barsness, Kathleen K; Suresh, Santhanam S

Paediatric anaesthesia. 2009 Sep 01;19(9):892-8. Epub 2009-07-13.

PubMed abstract

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