Andrew P. Ambrosy, MD

andrew.p.ambrosy@kp.org

Andrew P. Ambrosy, MD, is a physician-scientist at the Kaiser Permanente Northern California (KPNC) Division of Research, with clinical and research expertise in cardiovascular, renal, and metabolic conditions. Dr. Ambrosy’s work focuses on generating real-world evidence through health services research, delivery science, and both traditional and pragmatic randomized controlled trials. His research program has been supported by grants from the NIH (K23HL150159 and R01AG091005), the AHA, internal funders, and industry sponsors, with notable ongoing projects including the use of natural language processing to capture and characterize heart failure, a pragmatic randomized controlled trial evaluating iron deficiency treatment in older adults with heart failure and a strategy randomized controlled trial designed to improve medication adherence in heart failure within a learning health system.

Dr. Ambrosy completed a two-year dedicated research fellowship at the Duke Clinical Research Institute, where he gained hands-on experience in clinical trial operations, including study design, site activation, recruitment/enrollment, and data and safety monitoring. During this time, Dr. Ambrosy was a key member of the operations team for the Data Coordinating Center and/or Clinical Coordination Center for the NHLBI-funded Heart Failure Clinical Research Network, as well as several industry-sponsored trials, including PIONEER-HF (sacubitril/valsartan) and HEART-FID (intravenous iron).

Dr. Ambrosy has presented his research at national and international scientific meetings and published over 225 peer-reviewed manuscripts. In addition, he serves as Editor-in-Chief of Heart Failure Reviews, as Associate Editor for the American Heart Journal, and is a member of the editorial board for the Journal of Cardiac Failure.

Current Positions

Staff Cardiologist, Department of Cardiology, The Permanente Medical Group, San Francisco
Research Scientist, Division of Research, Kaiser Permanente Northern California
Associate Program Director for Research (Fellowship), Department of Cardiology, The Permanente Medical Group, San Francisco
Local Research Chair, The Permanente Medical Group, San Francisco

Section Affiliations

Cardiovascular and Metabolic Conditions

Primary Research Interests

Ischemia Heart Disease
Cardiomyopathy
Heart Failure
Health Outcomes
Implementation Science
Clinical Trials

Studies

Improving Care by Defining the Role of ElectroNic HealTh Record-Based Alerts In a Fully Integrated Health Care Delivery SYstem for Worsening Heart Failure (IDENTIFY-WHF)

IDENTIFY-WHF is a prospective, virtual, parallel-group, randomized, quality improvement intervention of EHR-based alerts for worsening heart failure (WHF) to improve the adoption of guideline-directed medical therapy (GDMT) within an integrated and learning health care delivery system. Approximately 1,000 participants will be randomized 1:1 to the intervention or usual standard of care. The primary outcome is the proportion of adults experiencing WHF with an increase in the number of prescribed GDMT classes at 30 days post-discharge from the hospital or ED.