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Ankeet Bhatt, MD, MBA, ScM

ankeet.s.bhatt@kp.org

Ankeet  Bhatt, MD, MBA, ScM

Ankeet S. Bhatt, MD, MBA, ScM is a research scientist at the Division of Research and an associate physician and practicing cardiologist and intensivist at the Kaiser Permanente San Francisco Medical Center. Dr. Bhatt’s research interests include cardio-renal-metabolic disease, with a particular focus on clinical trials, heart failure, shock, and implementation and care delivery science.

Dr. Bhatt earned his undergraduate degree in biological sciences at the University of Connecticut, where he completed both medical and business training in a joint MD/MBA program. He completed his residency at the Duke University Hospital in Durham, NC, followed by fellowships in cardiovascular diseases and critical care medicine at the Brigham and Women’s Hospital and Harvard Medical School in Boston, MA. He completed a 2-year research fellowship under the mentorship of Drs. Scott Solomon, David Morrow, Marc Pfeffer, and Muthiah Vaduganathan at Harvard Medical School and earned a Master of Science in Epidemiology from the Harvard T.H. Chan School of Public Health.

Dr. Bhatt has presented his research at national and international scientific congresses and participates in the leadership of several large implementation science trials in cardiovascular disease. He has authored more than 60 peer-reviewed manuscripts and currently serves as the Section Editor of Implementation & Care Delivery Science for the Journal of Cardiac Failure.

Current Positions

  • Research Scientist, Division of Research, Kaiser Permanente Northern California, Oakland, CA
  • Associate Physician, Department of Cardiology, Kaiser San Francisco Medical Center, San Francisco, CA

Section Affiliations

Primary Research Interests

  • Implementation and Care Delivery Science
  • Clinical Trials
  • Heart Failure
  • Cardiogenic Shock
  • Cardiometabolic Disease

Studies

Nationwide Utilization of Danish Government Electronic Letter System for Increasing InFLUenza Vaccine Uptake (NUDGE-FLU)

NUDGE-FLU was a nationwide, pragmatic, registry-based, cluster-randomized implementation trial during the 2022-23 influenza season in Denmark. NUDGE FLU randomized >960,000 Danish citizens aged 65 years or older to usual care or 9 different behaviorally informed electronic letters (9:1:1:1:1:1:1:1:1:1) promoting influenza vaccination. Letters explaining the potential cardiovascular benefits of influenza vaccination demonstrated a modest but significant improvement in vaccination uptake, a finding which was particularly pronounced in patients without vaccination in the prior influenza season, potentially indicating the ability to nudge a vaccine hesitant group.

Investigator: Bhatt, Ankeet

Funder: Sanofi Pasteur S.A.

TRANSFORM3: Evaluation of Implementation Strategies of Teaching, Technology, and Teams to Optimize Medical Therapy in Cardiovascular Disease (“T3”)

This initiative evaluates strategies (including technology-based decision support, referral to a virtual guideline-directed medical therapy team, and general educational tools/resources for clinicians and patients) to improve use of guideline-directed therapeutics known to lower cardiovascular events among patients with heart failure, atrial fibrillation and type 2 diabetes/ arteriosclerotic cardiovascular disease.

Investigator: Bhatt, Ankeet

Funder: American College of Cardiology Foundation

Coronary Artery Risk Development in Young Adults (CARDIA)

This landmark 35-year study describes the distribution of coronary heart disease risk factors in a biracial cohort of men and women aged 18 to 30 years at entry; and identifies habits, behaviors and lifestyles that are associated with initial levels of risk factors, with the evolution of risk factors, and increasingly with clinical events.

Investigator: Bhatt, Ankeet

Funder: National Heart, Lung, and Blood Institute

Publications

Operational Challenges and Mitigation Measures During the COVID-19 Pandemic – Lessons From DELIVER

Authors: Bhatt, Ankeet S;Solomon, Scott D;et al.

Am Heart J. 2023 Sep;263:133-140. Epub 2023-05-21.

PubMed abstract

Influence of background medical therapy on efficacy and safety of dapagliflozin in patients with heart failure with improved ejection fraction in the DELIVER trial

Authors: Pabon, Maria;Chatur, Safia;Vardeny, Orly;et al.

Eur J Heart Fail. 2023 Aug 26.

PubMed abstract

Heart Failure Medical Therapy Prior to Mitral Transcatheter Edge-to-Edge Repair: The STS/ACC Transcatheter Valve Therapy Registry

Authors: Varshney, Anubodh S;Kosinski, Andrzej;Vaduganathan, Muthiah;et al.

Eur Heart J. 2023 Aug 26.

PubMed abstract

Understanding cardiohepatic interactions in patients with heart failure with mildly reduced or preserved ejection fraction

Authors: Chang, Alex J;Bhatt, Ankeet S;Ambrosy, Andrew P

Eur J Heart Fail. 2023 Aug;25(8):1384-1385. Epub 2023-07-10.

PubMed abstract

Special DELIVERy: reducing high-complexity hospitalizations in heart failure

Authors: Gustafson, Shanshan E;Ambrosy, Andrew P;Bhatt, Ankeet S

Eur J Heart Fail. 2023 Aug;25(8):1372-1374. Epub 2023-07-11.

PubMed abstract

Effect of the P-selectin Inhibitor Crizanlizumab on Survival Free of Organ Support in Patients Hospitalized for COVID-19: A Randomized Controlled Trial

Authors: Solomon, Scott D;Lowenstein, Charles J;ACTIV4a Investigators,;et al.

Circulation. 2023 Aug;148(5):381-390. Epub 2023-06-25.

PubMed abstract

Electronic nudges to increase influenza vaccination uptake among patients with heart failure: a prespecified analysis of the NUDGE-FLU trial

Authors: Johansen, Niklas Dyrby;Vaduganathan, Muthiah;Biering-Sørensen, Tor;et al.

Eur J Heart Fail. 2023 Aug;25(8):1450-1458. Epub 2023-06-04.

PubMed abstract

Effect of Dapagliflozin on Health Status and Quality-of-Life Across the Spectrum of Ejection Fraction: Participant-Level Pooled Analysis from the DAPA-HF & DELIVER Trials

Authors: Bhatt, Ankeet S;Solomon, Scott D;et al.

Eur J Heart Fail. 2023 Jul;25(7):981-988. Epub 2023-06-07.

PubMed abstract

Nationwide Utilization of Danish Government Electronic Letter System for Increasing InFLUenza Vaccine Uptake (NUDGE-FLU): Study Protocol for a Nationwide Randomized Implementation Trial

Authors: Johansen, Niklas Dyrby; Bhatt, Ankeet S; Biering-Sørensen, Tor; et al.

Am Heart J. 2023 Jun;260:58-71. Epub 2023-02-17.

PubMed abstract

Association Between Participation in a Heart Failure Telemonitoring Program and Healthcare Utilization and Death within an Integrated Health Care Delivery System

Authors: Parikh, Rishi V;Axelrod, Amir W;Ambrosy, Andrew P;Tan, Thida C;Bhatt, Ankeet S;Fitzpatrick, Jesse K;Lee, Keane K;Aditya, Sirtaz;Vasadia, Jitesh V;Dinh, Howard H;Go, Alan S

J Card Fail. 2023 May 21.

PubMed abstract

The Effect of Electronic Nudges on Influenza Vaccination Rate in Older Adults With Cardiovascular Disease: a Prespecified Analysis of the NUDGE-FLU Trial

Authors: Modin, Daniel; Bhatt, Ankeet S; Biering-Sørensen, Tor; et al.

Circulation. 2023 May 02;147(18):1345-1354. Epub 2023-03-05.

PubMed abstract

Virtual Care Team-Guided Therapeutic Optimization During Hospitalization in Patients with Heart Failure: The IMPLEMENT-HF Study

Authors: Bhatt, Ankeet S; Vaduganathan, Muthiah; et al.

J Am Coll Cardiol. 2023 May 02;81(17):1680-1693. Epub 2023-03-06.

PubMed abstract

Multi-Marker Risk Assessment in Patients Hospitalized with COVID-19: Results from the American Heart Association COVID-19 Cardiovascular Disease Registry

Authors: Bhatt, Ankeet S; Daniels, Lori B; de Lemos, James; Goodrich, Erica; Bohula, Erin A; Morrow, David A

Am Heart J. 2023 Apr;258:149-156. Epub 2023-01-18.

PubMed abstract

Electronic nudges to increase influenza vaccination uptake in Denmark: a nationwide, pragmatic, registry-based, randomised implementation trial

Authors: Johansen, Niklas Dyrby; Bhatt, Ankeet S; Biering-Sørensen, Tor; et al.

Lancet. 2023 Apr 01;401(10382):1103-1114. Epub 2023-03-05.

PubMed abstract

Effect of Dapagliflozin on Health Status in Patients With Preserved or Mildly Reduced Ejection Fraction

Authors: Kosiborod, Mikhail N; Bhatt, Ankeet S; Solomon, Scott D; et al.

J Am Coll Cardiol. 2023 Feb 07;81(5):460-473. Epub 2022-12-14.

PubMed abstract

Strategic transformations in academic clinical medicine.

Authors: Bhatt, Ankeet S; Deckers, Peter J

Conn Med. 2014 Jun-Jul;78(6):357-61.

PubMed abstract

Curious Crosses: Injection-Induced Lesions.

Authors: Bhatt, Ankeet S; Perkins, Scott; McKinnon, Elizabeth; Perfect, John R

Am J Med. 2017 Jan;130(1):31-33. doi: 10.1016/j.amjmed.2016.08.023. Epub 2016 Sep 9.

PubMed abstract

Interaction of Body Mass Index on the Association Between N-Terminal-Pro-b-Type Natriuretic Peptide and Morbidity and Mortality in Patients With Acute Heart Failure: Findings From ASCEND-HF (Acute Study of Clinical Effectiveness of Nesiritide in Decompensated Heart Failure).

Authors: Bhatt, Ankeet S; Cooper, Lauren B; Ambrosy, Andrew P; Clare, Robert M; Coles, Adrian; Joyce, Emer; Krishnamoorthy, Arun; Butler, Javed; Felker, G Michael; Ezekowitz, Justin A; Armstrong, Paul W; Hernandez, Adrian F; O'Connor, Christopher M; Mentz, Robert J

J Am Heart Assoc. 2018 Feb 3;7(3). pii: JAHA.117.006740. doi: 10.1161/JAHA.117.006740.

PubMed abstract

Adverse Remodeling and Reverse Remodeling After Myocardial Infarction.

Authors: Bhatt, Ankeet S; Ambrosy, Andrew P; Velazquez, Eric J

Curr Cardiol Rep. 2017 Aug;19(8):71. doi: 10.1007/s11886-017-0876-4.

PubMed abstract

Trajectory of Congestion Metrics by Ejection Fraction in Patients With Acute Heart Failure (from the Heart Failure Network).

Authors: Ambrosy, Andrew P; Bhatt, Ankeet S; Gallup, Dianne; Anstrom, Kevin J; Butler, Javed; DeVore, Adam D; Felker, G Michael; Fudim, Marat; Greene, Stephen J; Hernandez, Adrian F; Kelly, Jacob P; Samsky, Marc D; Mentz, Robert J

Am J Cardiol. 2017 Jul 1;120(1):98-105. doi: 10.1016/j.amjcard.2017.03.249. Epub 2017 Apr 12.

PubMed abstract

Achieving a Maximally Tolerated beta-Blocker Dose in Heart Failure Patients: Is There Room for Improvement?

Authors: Bhatt, Ankeet S; DeVore, Adam D; DeWald, Tracy A; Swedberg, Karl; Mentz, Robert J

J Am Coll Cardiol. 2017 May 23;69(20):2542-2550. doi: 10.1016/j.jacc.2017.03.563.

PubMed abstract

Can Vaccinations Improve Heart Failure Outcomes?: Contemporary Data and Future Directions.

Authors: Bhatt, Ankeet S; DeVore, Adam D; Hernandez, Adrian F; Mentz, Robert J

JACC Heart Fail. 2017 Mar;5(3):194-203. doi: 10.1016/j.jchf.2016.12.007. Epub 2017 Feb 1.

PubMed abstract

Improving operating room turnover time: a systems based approach.

Authors: Bhatt, Ankeet S; Carlson, Grant W; Deckers, Peter J

J Med Syst. 2014 Dec;38(12):148. doi: 10.1007/s10916-014-0148-4. Epub 2014 Nov 8.

PubMed abstract

Prevalent digoxin use and subsequent risk of death or hospitalization in ambulatory heart failure patients with a reduced ejection fraction-Findings from the Heart Failure: A Controlled Trial Investigating Outcomes of Exercise Training (HF-ACTION) randomized controlled trial.

Authors: Ambrosy, Andrew P; Bhatt, Ankeet S; Stebbins, Amanda L; Wruck, Lisa M; Fudim, Marat; Greene, Stephen J; Kraus, William E; O'Connor, Christopher M; Pina, Ileana L; Whellan, David J; Mentz, Robert J

Am Heart J. 2018 May;199:97-104. doi: 10.1016/j.ahj.2018.02.004. Epub 2018 Feb 11.

PubMed abstract

Fewer Hospitalizations for Acute Cardiovascular Conditions During the COVID-19 Pandemic.

Authors: Bhatt, Ankeet S; Moscone, Alea; McElrath, Erin E; Varshney, Anubodh S; Claggett, Brian L; Bhatt, Deepak L; Januzzi, James L; Butler, Javed; Adler, Dale S; Solomon, Scott D; Vaduganathan, Muthiah

J Am Coll Cardiol. 2020 Jul 21;76(3):280-288. doi: 10.1016/j.jacc.2020.05.038. Epub 2020 May 26.

PubMed abstract

Post-discharge haemodilution, congestion, and clinical outcomes among patients hospitalized for heart failure with reduced ejection fraction: results from the EVEREST trial.

Authors: Bhatt, Ankeet S; Vaduganathan, Muthiah; Patel, Ravi B; Fonarow, Gregg C; Subacius, Haris P; Konstam, Marvin A; Zannad, Faiez; Butler, Javed; Greene, Stephen J

Eur J Heart Fail. 2020 Jan;22(1):164-167. doi: 10.1002/ejhf.1651. Epub 2019 Dec 3.

PubMed abstract

International variation in characteristics and clinical outcomes of patients with type 2 diabetes and heart failure: Insights from TECOS.

Authors: Bhatt, Ankeet S; Luo, Nancy; Solomon, Nicole; Pagidipati, Neha J; Ambrosio, Giuseppe; Green, Jennifer B; McGuire, Darren K; Standl, Eberhard; Cornel, Jan H; Halvorsen, Sigrun; Lopes, Renato D; White, Harvey D; Holman, Rury R; Peterson, Eric D; Mentz, Robert J

Am Heart J. 2019 Dec;218:57-65. doi: 10.1016/j.ahj.2019.08.016. Epub 2019 Aug 28.

PubMed abstract

Influenza Vaccination in Patients With Heart Failure.

Authors: DeVore, Adam D; Bhatt, Ankeet S

Circulation. 2019 Jan 29;139(5):587-589. doi: 10.1161/CIRCULATIONAHA.118.038348.

PubMed abstract

Reply: Vaccination in Patients With Heart Failure: An Established Recommendation in Patients With Chronic Heart Disease.

Authors: Bhatt, Ankeet S; DeVore, Adam D; Hernandez, Adrian F

JACC Heart Fail. 2019 Jan;7(1):85. doi: 10.1016/j.jchf.2018.11.015.

PubMed abstract

Loop diuretic adjustments in patients with chronic heart failure: Insights from HF-ACTION.

Authors: Fudim, Marat; O'Connor, Christopher M; Mulder, Hillary; Coles, Adrian; Bhatt, Ankeet S; Ambrosy, Andrew P; Kraus, William E; Pina, Ileana L; Whellan, David J; Mentz, Robert J

Am Heart J. 2018 Nov;205:133-141. doi: 10.1016/j.ahj.2018.06.017. Epub 2018 Jul 29.

PubMed abstract

Vaccination Trends in Patients With Heart Failure: Insights From Get With The Guidelines-Heart Failure.

Authors: Bhatt, Ankeet S; Liang, Li; DeVore, Adam D; Fonarow, Gregg C; Solomon, Scott D; Vardeny, Orly; Yancy, Clyde W; Mentz, Robert J; Khariton, Yevgeniy; Chan, Paul S; Matsouaka, Roland; Lytle, Barbara L; Pina, Ileana L; Hernandez, Adrian F

JACC Heart Fail. 2018 Oct;6(10):844-855. doi: 10.1016/j.jchf.2018.04.012. Epub 2018 Aug 8.

PubMed abstract

Discovery and care innovation amidst a pandemic.

Authors: Bhatt, Ankeet S; Vaduganathan, Muthiah

Eur J Heart Fail. 2020 Dec;22(12):2202-2204. doi: 10.1002/ejhf.2070. Epub 2020 Dec 14.

PubMed abstract

Innovation in Ambulatory Care of Heart Failure in the Era of Coronavirus Disease 2019.

Authors: Leiva, Orly; Bhatt, Ankeet S; Vaduganathan, Muthiah

Heart Fail Clin. 2020 Oct;16(4):433-440. doi: 10.1016/j.hfc.2020.06.004. Epub 2020 Jun 19.

PubMed abstract

Clinical Outcomes in Young US Adults Hospitalized With COVID-19.

Authors: Cunningham, Jonathan W; Vaduganathan, Muthiah; Claggett, Brian L; Jering, Karola S; Bhatt, Ankeet S; Rosenthal, Ning; Solomon, Scott D

JAMA Intern Med. 2020 Sep 9. pii: 2770542. doi: 10.1001/jamainternmed.2020.5313.

PubMed abstract

A Man in His 30s With a New Continuous Murmur and Fever.

Authors: Li, Selena; Bhatt, Ankeet S; O'Gara, Patrick T

JAMA Cardiol. 2020 Aug 1;5(8):e203255. doi: 10.1001/jamacardio.2020.3255. Epub 2020 Aug 19.

PubMed abstract

Growing Mismatch Between Evidence Generation and Implementation in Heart Failure.

Authors: Bhatt, Ankeet S; Vaduganathan, Muthiah; Butler, Javed

Am J Med. 2020 May;133(5):525-527. doi: 10.1016/j.amjmed.2019.11.032. Epub 2020 Jan 17.

PubMed abstract

Angiotensin-neprilysin inhibition in de novo heart failure – starting off strong.

Authors: Bhatt, Ankeet S; Vaduganathan, Muthiah; Butler, Javed

Eur J Heart Fail. 2020 Feb;22(2):313-314. doi: 10.1002/ejhf.1675. Epub 2019 Dec 16.

PubMed abstract

Conduct of Clinical Trials in the Era of COVID-19: JACC Scientific Expert Panel.

Authors: Psotka, Mitchell A; Abraham, William T; Fiuzat, Mona; Filippatos, Gerasimos; Lindenfeld, JoAnn; Ahmad, Tariq; Bhatt, Ankeet S; Carson, Peter E; Cleland, John G F; Felker, G Michael; Januzzi, James L Jr; Kitzman, Dalane W; Leifer, Eric S; Lewis, Eldrin F; McMurray, John J V; Mentz, Robert J; Solomon, Scott D; Stockbridge, Norman; Teerlink, John R; Vaduganathan, Muthiah; Vardeny, Orly; Whellan, David J; Wittes, Janet; Anker, Stefan D; O'Connor, Christopher M

J Am Coll Cardiol. 2020 Nov 17;76(20):2368-2378. doi: 10.1016/j.jacc.2020.09.544.

PubMed abstract

Clinical Outcomes in Patients With Heart Failure Hospitalized With COVID-19.

Authors: Bhatt, Ankeet S; Jering, Karola S; Vaduganathan, Muthiah; Claggett, Brian L; Cunningham, Jonathan W; Rosenthal, Ning; Signorovitch, James; Thune, Jens J; Vardeny, Orly; Solomon, Scott D

JACC Heart Fail. 2021 Jan;9(1):65-73. doi: 10.1016/j.jchf.2020.11.003.

PubMed abstract

Treatment of HF in an Era of Multiple Therapies: Statement From the HF Collaboratory.

Authors: Bhatt, Ankeet S; Abraham, William T; Lindenfeld, JoAnn; Bristow, Michael; Carson, Peter E; Felker, G Michael; Fonarow, Gregg C; Greene, Stephen J; Psotka, Mitchell A; Solomon, Scott D; Stockbridge, Norman; Teerlink, John R; Vaduganathan, Muthiah; Wittes, Janet; Fiuzat, Mona; O'Connor, Christopher M; Butler, Javed

JACC Heart Fail. 2021 Jan;9(1):1-12. doi: 10.1016/j.jchf.2020.10.014. Epub 2020 Dec 9.

PubMed abstract

Bias in natriuretic peptide-guided heart failure trials: time to improve guideline adherence using alternative approaches.

Authors: Stienen, Susan; Bhatt, Ankeet; Ferreira, Joao Pedro; Vaduganathan, Muthiah; Januzzi, James; Adams, Kirkwood; Tardif, Jean-Claude; Rossignol, Patrick; Zannad, Faiez

Heart Fail Rev. 2021 Jan;26(1):11-21. doi: 10.1007/s10741-020-10004-6.

PubMed abstract

Practice pattern of use of high sensitivity troponin in the outpatient settings.

Authors: Ferro, Enrico G; Bhatt, Ankeet S; Zhou, Guohai; Fiumara, Karen; Wasfy, Jason H; Sequist, Thomas D; Morrow, David A; Scirica, Benjamin M

Clin Cardiol. 2020 Dec;43(12):1573-1578. doi: 10.1002/clc.23482. Epub 2020 Oct 22.

PubMed abstract

Reply: Are We Missing Something in the Management of Acute Coronary Syndromes in COVID-19-Negative Patients?

Authors: Bhatt, Ankeet S; Vaduganathan, Muthiah

J Am Coll Cardiol. 2020 Nov 24;76(21):2574-2575. doi: 10.1016/j.jacc.2020.09.548.

PubMed abstract

Accuracy of ICD-10 Diagnostic Codes to Identify COVID-19 Among Hospitalized Patients.

Authors: Bhatt, Ankeet S; McElrath, Erin E; Claggett, Brian L; Bhatt, Deepak L; Adler, Dale S; Solomon, Scott D; Vaduganathan, Muthiah

J Gen Intern Med. 2021 Aug;36(8):2532-2535. doi: 10.1007/s11606-021-06936-w. Epub 2021 Jun 7.

PubMed abstract

Virtual optimization of guideline-directed medical therapy in hospitalized patients with heart failure with reduced ejection fraction: the IMPLEMENT-HF pilot study.

Authors: Bhatt, Ankeet S; Varshney, Anubodh S; Nekoui, Mahan; Moscone, Alea; Cunningham, Jonathan W; Jering, Karola S; Patel, Parth N; Sinnenberg, Lauren E; Bernier, Thomas D; Buckley, Leo F; Cook, Bryan M; Dempsey, Jillian; Kelly, Julie; Knowles, Danielle M; Lupi, Kenneth; Malloy, Rhynn; Matta, Lina S; Rhoten, Megan N; Sharma, Krishan; Snyder, Caroline A; Ting, Clara; McElrath, Erin E; Amato, Mary G; Alobaidly, Maryam; Ulbricht, Catherine E; Choudhry, Niteesh K; Adler, Dale S; Vaduganathan, Muthiah

Eur J Heart Fail. 2021 Jul;23(7):1191-1201. doi: 10.1002/ejhf.2163. Epub 2021 Apr 13.

PubMed abstract

Influenza vaccination: a ‘shot’ at INVESTing in cardiovascular health.

Authors: Bhatt, Ankeet S; Vardeny, Orly; Udell, Jacob A; Joseph, Jacob; Kim, KyungMann; Solomon, Scott D

Eur Heart J. 2021 May 21;42(20):2015-2018. doi: 10.1093/eurheartj/ehab133.

PubMed abstract

For vaptans, as for life, balance is better.

Authors: Bhatt, Ankeet S; Yanamandala, Mounica; Konstam, Marvin A

Eur J Heart Fail. 2021 May;23(5):751-753. doi: 10.1002/ejhf.2042. Epub 2020 Nov 18.

PubMed abstract

Incidence and Outcomes of Pneumonia in Patients With Heart Failure.

Authors: Shen, Li; Jhund, Pardeep S; Anand, Inder S; Bhatt, Ankeet S; Desai, Akshay S; Maggioni, Aldo P; Martinez, Felipe A; Pfeffer, Marc A; Rizkala, Adel R; Rouleau, Jean L; Swedberg, Karl; Vaduganathan, Muthiah; Vardeny, Orly; van Veldhuisen, Dirk J; Zannad, Faiez; Zile, Michael R; Packer, Milton; Solomon, Scott D; McMurray, John J V

J Am Coll Cardiol. 2021 Apr 27;77(16):1961-1973. doi: 10.1016/j.jacc.2021.03.001.

PubMed abstract

Reply: Improving Heart Failure Therapeutics: Thinking Outside the Pillbox?

Authors: Bhatt, Ankeet S; Fiuzat, Mona; Lindenfeld, JoAnn; O'Connor, Christopher M; Butler, Javed

JACC Heart Fail. 2021 Apr;9(4):320-321. doi: 10.1016/j.jchf.2021.01.005.

PubMed abstract

Characteristics of clinical trials evaluating cardiovascular therapies for Coronavirus Disease 2019 Registered on ClinicalTrials.gov: a cross sectional analysis.

Authors: Varshney, Anubodh S; Wang, David E; Bhatt, Ankeet S; Blood, Alexander; Sharkawi, Musa A; Siddiqi, Hasan K; Vaduganathan, Muthiah; Monteleone, Peter P; Patel, Manesh R; Jones, W Schuyler; Lopes, Renato D; Mehra, Mandeep R; Bhatt, Deepak L; Kochar, Ajar

Am Heart J. 2021 Feb;232:105-115. doi: 10.1016/j.ahj.2020.10.065. Epub 2020 Oct 26.

PubMed abstract

Evidence-Based Prescribing and Polypharmacy for Patients With Heart Failure.

Authors: Bhatt, Ankeet S; Choudhry, Niteesh K

Ann Intern Med. 2021 Aug;174(8):1165-1166. doi: 10.7326/M21-1427. Epub 2021 Jun 29.

PubMed abstract

Treatment Effects of Sacubitril/Valsartan Compared With Valsartan by Ejection Fraction in Patients With Recent Hospitalization.

Authors: Bhatt, Ankeet S; Claggett, Brian L; Packer, Milton; Lefkowitz, Martin P; Zile, Michael R; McMurray, John J V; Solomon, Scott D; Vaduganathan, Muthiah

J Card Fail. 2021 Sep;27(9):1027-1030. doi: 10.1016/j.cardfail.2021.05.020. Epub 2021 Jun 13.

PubMed abstract

Effect of sacubitril/valsartan vs. enalapril on changes in heart failure therapies over time: the PARADIGM-HF trial.

Authors: Bhatt, Ankeet S; Vaduganathan, Muthiah; Claggett, Brian L; Liu, Jiankang; Packer, Milton; Desai, Akshay S; Lefkowitz, Martin P; Rouleau, Jean L; Shi, Victor C; Zile, Michael R; Swedberg, Karl; Vardeny, Orly; McMurray, John J V; Solomon, Scott D

Eur J Heart Fail. 2021 Sep;23(9):1518-1524. doi: 10.1002/ejhf.2259. Epub 2021 Jun 21.

PubMed abstract

Hospitalization of Patients With (But Not for) Heart Failure: An Opportunity for Accelerated Guideline-Directed Medical Therapy Optimization?

Authors: Varshney, Anubodh S; Bhatt, Ankeet S; Vaduganathan, Muthiah

J Card Fail. 2021 Aug;27(8):910-912. doi: 10.1016/j.cardfail.2021.04.004.

PubMed abstract

Prioritizing Dissemination and Implementation Science in Cardiometabolic Medicine: CONNECTing the Dots.

Authors: Bhatt, Ankeet S; Solomon, Scott D; Vaduganathan, Muthiah

JAMA. 2021 Jul 27;326(4):311-313. doi: 10.1001/jama.2021.9847.

PubMed abstract

Prognostic Value of Natriuretic Peptides and Cardiac Troponins in COVID-19.

Authors: Cunningham, Jonathan W; Claggett, Brian L; Jering, Karola S; Vaduganathan, Muthiah; Bhatt, Ankeet S; Rosenthal, Ning; Solomon, Scott D

Circulation. 2021 Jul 13;144(2):177-179. doi: 10.1161/CIRCULATIONAHA.121.054969. Epub 2021 May 17.

PubMed abstract

Coronavirus Disease-2019 and Heart Failure: A Scientific Statement From the Heart Failure Society of America.

Authors: Bhatt, Ankeet S; Adler, Eric D; Albert, Nancy M; Anyanwu, Anelechi; Bhadelia, Nahid; Cooper, Leslie T; Correa, Ashish; Defilippis, Ersilia M; Joyce, Emer; Sauer, Andrew J; Solomon, Scott D; Vardeny, Orly; Yancy, Clyde; Lala, Anuradha

J Card Fail. 2022 Jan;28(1):93-112. doi: 10.1016/j.cardfail.2021.08.013. Epub 2021 Sep 1.

PubMed abstract

Adherence to Evidence-Based Therapies in Heart Failure: Deepening the Implementation Divide.

Authors: Bhatt, Ankeet S

JACC Heart Fail. 2021 Dec;9(12):887-889. doi: 10.1016/j.jchf.2021.07.007. Epub 2021 Sep 8.

PubMed abstract

Potential Implications of Expanded US Food and Drug Administration Labeling for Sacubitril/Valsartan in the US.

Authors: Vaduganathan, Muthiah; Claggett, Brian L; Greene, Stephen J; Aggarwal, Rahul; Bhatt, Ankeet S; McMurray, John J V; Fonarow, Gregg C; Solomon, Scott D

JAMA Cardiol. 2021 Dec 1;6(12):1415-1423. doi: 10.1001/jamacardio.2021.3651.

PubMed abstract

Epidemiology of Cardiogenic Shock in Hospitalized Adults With COVID-19: A Report From the American Heart Association COVID-19 Cardiovascular Disease Registry.

Authors: Varshney, Anubodh S; Omar, Wally A; Goodrich, Erica L; Bhatt, Ankeet S; Wolley, Ann E; Gong, Jingyi; Senman, Balimkiz C; Silva, Danuzia; Levangie, Michael W; Berg, David D; Yeh, Robert W; de Lemos, James A; Morrow, David A; Kazi, Dhruv S; Bohula, Erin A

Circ Heart Fail. 2021 Dec;14(12):e008477. doi: 10.1161/CIRCHEARTFAILURE.121.008477. Epub 2021 Nov 18.

PubMed abstract

De Novo vs Acute-on-Chronic Presentations of Heart Failure-Related Cardiogenic Shock: Insights from the Critical Care Cardiology Trials Network Registry.

Authors: Bhatt, Ankeet S; Berg, David D; Bohula, Erin A; Alviar, Carlos L; Baird-Zars, Vivian M; Barnett, Christopher F; Burke, James A; Carnicelli, Anthony P; Chaudhry, Sunit-Preet; Daniels, Lori B; Fang, James C; Fordyce, Christopher B; Gerber, Daniel A; Guo, Jianping; Jentzer, Jacob C; Katz, Jason N; Keller, Norma; Kontos, Michael C; Lawler, Patrick R; Menon, Venu; Metkus, Thomas S; Nativi-Nicolau, Jose; Phreaner, Nicholas; Roswell, Robert O; Sinha, Shashank S; Jeffrey Snell, R; Solomon, Michael A; Van Diepen, Sean; Morrow, David A

J Card Fail. 2021 Oct;27(10):1073-1081. doi: 10.1016/j.cardfail.2021.08.014.

PubMed abstract

Prioritizing prevention of de novo and worsening chronic heart failure.

Authors: Bhatt, Ankeet S; Fonarow, Gregg C; Greene, Stephen J

Eur J Heart Fail. 2022 Apr;24(4):653-656. doi: 10.1002/ejhf.2464. Epub 2022 Mar 15.

PubMed abstract

Cost and Value in Contemporary Heart Failure Clinical Guidance Documents.

Authors: Ostrominski, John W; Hirji, Sameer; Bhatt, Ankeet S; Butler, Javed; Fiuzat, Mona; Fonarow, Gregg C; Heidenreich, Paul A; Januzzi, James L Jr; Lam, Carolyn S P; Maddox, Thomas M; O'Connor, Christopher M; Vaduganathan, Muthiah

JACC Heart Fail. 2022 Jan;10(1):1-11. doi: 10.1016/j.jchf.2021.08.002. Epub 2021 Nov 10.

PubMed abstract

Relationship Between Myocardial Injury During Index Hospitalization for SARS-CoV-2 Infection and Longer-Term Outcomes.

Authors: Weber, Brittany; Siddiqi, Hasan; Zhou, Guohai; Vieira, Jefferson; Kim, Andy; Rutherford, Henry; Mitre, Xhoi; Feeley, Monica; Oganezova, Karina; Varshney, Anubodh S; Bhatt, Ankeet S; Nauffal, Victor; Atri, Deepak S; Blankstein, Ron; Karlson, Elizabeth W; Di Carli, Marcelo; Baden, Lindsey R; Bhatt, Deepak L; Woolley, Ann E

J Am Heart Assoc. 2022 Jan 4;11(1):e022010. doi: 10.1161/JAHA.121.022010. Epub 2021 Dec 31.

PubMed abstract

Personalizing Comprehensive Disease-Modifying Therapy: Obstacles and Opportunities.

Authors: Bhatt, Ankeet S; Vaduganathan, Muthiah; Ibrahim, Nasrien E

JACC Heart Fail. 2022 Feb;10(2):85-88. doi: 10.1016/j.jchf.2021.10.008. Epub 2021 Dec 8.

PubMed abstract

Reply: Bounded Rationality and Clinical Guidance Documents for Heart Failure.

Authors: Ostrominski, John W; Hirji, Sameer; Bhatt, Ankeet S; Vaduganathan, Muthiah

JACC Heart Fail. 2022 Mar;10(3):213-214. doi: 10.1016/j.jchf.2022.01.002.

PubMed abstract

Sodium-Glucose Cotransporter 2 Inhibitors and Cardiac Remodeling.

Authors: Salah, Husam M; Verma, Subodh; Santos-Gallego, Carlos G; Bhatt, Ankeet S; Vaduganathan, Muthiah; Khan, Muhammad Shahzeb; Lopes, Renato D; Al'Aref, Subhi J; McGuire, Darren K; Fudim, Marat

J Cardiovasc Transl Res. 2022 Mar 15. pii: 10.1007/s12265-022-10220-5. doi: 10.1007/s12265-022-10220-5.

PubMed abstract

Epidemiology of Acute Heart Failure in Critically Ill Patients With COVID-19: An Analysis From the Critical Care Cardiology Trials Network.

Authors: Berg, David D; Alviar, Carlos L; Bhatt, Ankeet S; Baird-Zars, Vivian M; Barnett, Christopher F; Daniels, Lori B; Defilippis, Andrew P; Fagundes, Antonio Jr; Katrapati, Praneeth; Kenigsberg, Benjamin B; Guo, Jianping; Keller, Norma; Lopes, Mathew S; Mody, Anika; Papolos, Alexander I; Phreaner, Nicholas; Sedighi, Romteen; Sinha, Shashank S; Toomu, Sandeep; Varshney, Anubodh S; Morrow, David A; Bohula, Erin A

J Card Fail. 2022 Apr;28(4):675-681. doi: 10.1016/j.cardfail.2021.12.020. Epub 2022 Jan 17.

PubMed abstract

The cardiovascular legacy of the COVID-19 pandemic.

Authors: Bhatt, Ankeet S; Vaduganathan, Muthiah

Eur Heart J. 2022 Sep 1;43(33):3179-3181. doi: 10.1093/eurheartj/ehac256.

PubMed abstract

Vaccines, Antibodies and Donors: Varying Attitudes and Policies Surrounding COVID-19 and Heart Transplantation.

Authors: Defilippis, Ersilia M; Allen, Larry A; Bhatt, Ankeet S; Joseph, Susan; Kittleson, Michelle; Vardeny, Orly; Drazner, Mark H; Lala, Anuradha

J Card Fail. 2022 Jun 16. pii: S1071-9164(22)00537-1. doi: 10.1016/j.cardfail.2022.05.009.

PubMed abstract

Epidemiology and Management of ST-Segment-Elevation Myocardial Infarction in Patients With COVID-19: A Report From the American Heart Association COVID-19 Cardiovascular Disease Registry.

Authors: Bhatt, Ankeet S; Varshney, Anubodh S; Goodrich, Erica L; Gong, Jingyi; Ginder, Curtis; Senman, Balimkiz C; Johnson, Matthew; Butler, Kayleigh; Woolley, Ann E; de Lemos, James A; Morrow, David A; Bohula, Erin A

J Am Heart Assoc. 2022 May 3;11(9):e024451. doi: 10.1161/JAHA.121.024451. Epub 2022 Apr 26.

PubMed abstract

Sacubitril/valsartan use patterns among older adults with heart failure in clinical practice: a population-based cohort study of >25 000 Medicare beneficiaries.

Authors: Bhatt, Ankeet S; Vaduganathan, Muthiah; Solomon, Scott D; Schneeweiss, Sebastian; Lauffenburger, Julie C; Desai, Rishi J

Eur J Heart Fail. 2022 Sep;24(9):1506-1515. doi: 10.1002/ejhf.2572. Epub 2022 Jun 22.

PubMed abstract

Building a Curriculum for the Cardiovascular Implementation Scientist.

Authors: Bhatt, Ankeet S; Lee, Simin; Vaduganathan, Muthiah

J Am Coll Cardiol. 2022 Sep 6;80(10):1023-1027. doi: 10.1016/j.jacc.2022.06.028.

PubMed abstract

Evaluating Implementation Approaches in Heart Failure: Ripe for rEVOLUTION

Authors: Bhatt, Ankeet S; Slade, Justin J

JACC Heart Fail. 2023 Jan;11(1):15-18. Epub 2022-12-07.

PubMed abstract

Investigating the Association Between Telemedicine Use and Timely Follow-Up Care After Acute Cardiovascular Hospital Encounters

Authors: Tang, Mitchell; Holmgren, A Jay; McElrath, Erin E; Bhatt, Ankeet S; Varshney, Anubodh S; Lee, Simin G; Vaduganathan, Muthiah; Adler, Dale S; Huckman, Robert S

JACC Adv. 2022 Dec;1(5):100156. Epub 2022-12-30.

PubMed abstract

Evaluating Digital Technologies for Implementation Science

Authors: Bhatt, Ankeet S

J Card Fail. 2022 10;28(10):1497-1499. Epub 2022-08-20.

PubMed abstract

Contemporary Burden of Primary Versus Secondary Heart Failure Hospitalizations in the United States

Authors: Varshney, Anubodh S; Minhas, Abdul Mannan Khan; Bhatt, Ankeet S; Ambrosy, Andrew P; Fudim, Marat; Vaduganathan, Muthiah

Am J Cardiol. 2021 10 01;156:140-142. Epub 2021-07-24.

PubMed abstract

The burden of non-cardiac comorbidities and association with clinical outcomes in an acute heart failure trial – insights from ASCEND-HF

Authors: Bhatt AS; Ambrosy AP; Mentz RJ; et al.

Eur J Heart Fail. 2020 06;22(6):1022-1031. Epub 2020-03-25.

PubMed abstract

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