Researchers expand understanding of hernia genetics
A Kaiser Permanente genetic analysis found 41 new locations on the human genome related to risk of hernia in the lower abdomen and identified for the first time 2 locations associated with inguinal hernia risk in people with African ancestry and another 8 that show sex-specific effects.
Unique genetic factors and ancestry, along with lifestyle, influence skin cancer risk
People can look to the Northern European side of their genetic heritage for increased risk of nonmelanoma skin cancer, according to the first large analysis of genetic risk factors for cutaneous squamous cell carcinoma in diverse populations with European ancestry from Kaiser Permanente researchers.
Genetic regions associated with corneal thickness identified by Kaiser Permanente researchers
The investigators wanted to better understand corneal thickness variation between individuals and its relationship with vision disorders such as primary open-angle glaucoma and keratoconus, which can both lead to vision loss.
How do patients’ genes affect their medication choice?
Analysis finds that neurological side effects from the anti-seizure medication phenytoin are more common in patients with certain genetic variants that were also associated with lower adherence to treatment, suggesting they may play a role in patients finding the right medication.
Kaiser Permanente Receives $7 Million to Better Identify Those at Risk of Getting Cancer
A research team at the Kaiser Permanente Northern California Division of Research has been awarded $7 million that will allow them to assess three different methods for acquiring and acting on family history, from initial acquisition to final results.
Kaiser Permanente Dataset Helps ID Dozens of Genetic Markers for Depression
By analyzing the genomes of people with depression and comparing them with the genomes of people without depression, a global team, including Kaiser Permanente researchers, identified 44 specific places in the human genome with links to depression.
Large Genome Study Reveals Record Number of DNA Loci Linked with Eye Pressure
Analysis of DNA from nearly 70,000 Kaiser Permanente Northern California patients uncovered 47 specific positions, or loci, in the genome that are associated with variations in pressure inside the eye. The findings could help clarify how elevated eye pressure leads to glaucoma.