Genetics Archives

Genomic risk scores may help identify patients at higher risk for coronary heart disease

April 5, 2024

Kaiser Permanente study finds a polygenic risk score might help physicians identify patients at higher risk of developing coronary heart disease.

Analysis reveals genetic clues to basal cell carcinoma risk

January 10, 2024

A large genetic analysis by Kaiser Permanente investigators identified 122 variations in the human genome related to basal cell carcinoma (BCC), 36 of them new.

5 Questions for…Hélène Choquet

September 8, 2022

Researcher Hélène Choquet, PhD, was in college studying biology when she heard about the first complete sequencing of the human genome; her interest in genetics has led her to a career exploring the genome for the origins of disease.

Gene tied to breast cancer treatment outcomes identified

March 24, 2022

Study led by Kaiser Permanente research scientist Lawrence H. Kushi, ScD, will help advance precision cancer care.

Researchers expand understanding of hernia genetics

January 20, 2022

A Kaiser Permanente genetic analysis found 41 new locations on the human genome related to risk of hernia in the lower abdomen and identified for the first time 2 locations associated with inguinal hernia risk in people with African ancestry and another 8 that show sex-specific effects.

Migraine genetics study finds intriguing connections with other medical conditions

July 22, 2021

A Kaiser Permanente genetic analysis found 82 locations on the human genome associated with migraine, 48 of them newly identified, including 3 specific to women, who experience migraine much more frequently than men.

Study identifies genetic clues for increased risk of age-related cataract

June 14, 2021

Using data from Kaiser Permanente and United Kingdom biobanks, researchers have identified new locations on the human genome that could relate to the risk of age-related cataract.

Unique genetic factors and ancestry, along with lifestyle, influence skin cancer risk

December 14, 2020

People can look to the Northern European side of their genetic heritage for increased risk of nonmelanoma skin cancer, according to the first large analysis of genetic risk factors for cutaneous squamous cell carcinoma in diverse populations with European ancestry from Kaiser Permanente researchers.

Genetic regions associated with corneal thickness identified by Kaiser Permanente researchers

June 11, 2020

The investigators wanted to better understand corneal thickness variation between individuals and its relationship with vision disorders such as primary open-angle glaucoma and keratoconus, which can both lead to vision loss.

Genetic underpinnings of near-sightedness identified in new research

March 30, 2020

New research involving Kaiser Permanente researchers and genetic data reveals for the first time which specific genes contribute to myopia risk.

How do patients’ genes affect their medication choice?

August 30, 2019

Analysis finds that neurological side effects from the anti-seizure medication phenytoin are more common in patients with certain genetic variants that were also associated with lower adherence to treatment, suggesting they may play a role in patients finding the right medication.

Large study links genetic marker of aging to greater neighborhood deprivation

May 6, 2019

Genetics research suggests that longer telomeres — the “end caps” of DNA that keep strands of chromosomes from unraveling — mean more years of healthy life ahead.

Kaiser Permanente Receives $7 Million to Better Identify Those at Risk of Getting Cancer

August 24, 2018

A research team at the Kaiser Permanente Northern California Division of Research has been awarded $7 million that will allow them to assess three different methods for acquiring and acting on family history, from initial acquisition to final results.

Kaiser Permanente Dataset Helps ID Dozens of Genetic Markers for Depression

April 30, 2018

By analyzing the genomes of people with depression and comparing them with the genomes of people without depression, a global team, including Kaiser Permanente researchers, identified 44 specific places in the human genome with links to depression.

Large Genome Study Reveals Record Number of DNA Loci Linked with Eye Pressure

December 15, 2017

Analysis of DNA from nearly 70,000 Kaiser Permanente Northern California patients uncovered 47 specific positions, or loci, in the genome that are associated with variations in pressure inside the eye. The findings could help clarify how elevated eye pressure leads to glaucoma.

New Autism Family Genetics Study Launches

April 1, 2015

A new Kaiser Permanente study will gather genetic material from 5,000 member families in order to undertake urgently needed research...

Grand Opportunity Creates Cutting-Edge Research Potential

August 7, 2013

By Ann Wallace, Senior Communications Specialist In 2009, the Research Program on Genes, Environment, and Health (RPGEH) received a Grand...

DNA of 100,000 Kaiser Permanente members genotyped in 15 months, creating novel resource for research

September 21, 2011

Resulting Data Will Provide Novel Resource for Accelerating Research One of the nation’s largest and most diverse genomics projects reached...

Blue Sky: Kaiser Permanente holds first symposium exploring future of autism research

April 28, 2011

Researchers from around the country gathered in San Francisco in early March to share information on the current state of...

Newly funded: $10.5M grant kickstarts national network to speed mental health research

April 18, 2011

A three-year $10.5 million federal grant awarded in December to help speed up mental health research will rely heavily on...

RPGEH: A world-class genomics project studying disease causes and healthy aging

February 2, 2011

It’s not every day Division of Research staff members are briefed by a Nobel Prize winner. Recently, 100 employees of...

Voice of the RPGEH: Marcia Ewing and the phone/survey team

January 30, 2011

It’s simply a case of cause and effect. To recruit 500,000 Northern California Kaiser Permanente members for a research project,...

RPGEH: Fast facts

January 29, 2011

Goal is database with 500,000 participants 430,000 have completed a health survey 170,000 gave saliva samples Future participants will be...

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