5 Questions for . . . Karen Jacobson
Karen Jacobson, MD, MPH, expected to study global health, but the COVID-19 pandemic shifted her focus to vaccines, and she joined the Vaccine Study Center as a research scientist.
Nirmatrelvir-Ritonavir and Symptoms in Adults With Postacute Sequelae of SARS-CoV-2 Infection: The STOP-PASC Randomized Clinical Trial
There is an urgent need to identify treatments for postacute sequelae of SARS-CoV-2 infection (PASC). To assess the efficacy of a 15-day course of nirmatrelvir-ritonavir in reducing the severity of select PASC symptoms. This was a 15-week blinded, placebo-controlled, randomized…
Monthly Sulfadoxine-Pyrimethamine During Pregnancy Prevents Febrile Respiratory Illnesses: A Secondary Analysis of a Malaria Chemoprevention Trial in Uganda
Trials evaluating antimalarials for intermittent preventive treatment in pregnancy (IPTp) have shown that dihydroartemisinin-piperaquine (DP) is a more efficacious antimalarial than sulfadoxine-pyrimethamine (SP); however, SP is associated with higher birthweight, suggesting that SP demonstrates "nonmalarial" effects. Chemoprevention of nonmalarial febrile…
Impact of gestational SARS-CoV-2 and maternal inflammation on child growth and neurodevelopment in a malaria-endemic setting
Leveraging longitudinal clinical data and samples from mother-infant dyads enrolled in two ongoing NIH-funded trials in Busia, Uganda, with high incidence of malaria and SARS-CoV-2, this study will evaluate the impact of gestational SARS-CoV-2 infection and vaccination on early childhood…
